本文選題：趨化因子CXC受體 + 趨化因子CXC配體��； 參考：《中國(guó)動(dòng)脈硬化雜志》2017年12期

【摘要】：目的探討趨化因子CX3C受體1(CX3CR1)基因rs3732378單核苷酸多態(tài)性與急性冠狀動(dòng)脈綜合征(ACS)的相關(guān)性。方法連續(xù)收集中國(guó)北方漢族人群951例,其中男性520例,女性431例,年齡35~75歲。根據(jù)冠狀動(dòng)脈造影(CAG)結(jié)果分為2組:(1)病例組(n=512):ACS患者;(2)對(duì)照組(n=439):非冠心病患者。病例組根據(jù)CAG檢查血管病變支數(shù)分為3個(gè)亞組。采用測(cè)序法測(cè)定CX3CR1基因rs3732378單核苷酸多態(tài)位點(diǎn)的基因型。用多因素Logistic回歸分析CX3CR1基因rs3732378多態(tài)性與ACS發(fā)病風(fēng)險(xiǎn)的關(guān)系。應(yīng)用酶聯(lián)免疫吸附法檢測(cè)血漿中趨化因子CX3C配體1(CX3CL1)表達(dá)水平。結(jié)果兩組CX3CR1基因rs3732378的基因型及等位基因的分布頻率無(wú)顯著性差異(P0.05)。rs3732378多態(tài)位點(diǎn)與ACS發(fā)病風(fēng)險(xiǎn)的總體和分層分析結(jié)果表明,CX3CR1基因rs3732378多態(tài)位點(diǎn)的3種基因型TT、TC和CC均不能增加ACS的發(fā)病風(fēng)險(xiǎn)(P0.05)。亞組分析顯示,rs3732378多態(tài)位點(diǎn)的基因型和等位基因與冠狀動(dòng)脈血管病變支數(shù)無(wú)相關(guān)性(χ2=0.135,P=0.998;χ2=0.026,P=0.987)。病例組和對(duì)照組血漿中CX3CL1表達(dá)水平在rs3732378三種基因型無(wú)差異(P0.05)。結(jié)論 CX3CR1基因rs3732378多態(tài)位點(diǎn)不是ACS的易感基因,rs3732378多態(tài)性沒(méi)有增加中國(guó)北方漢族人群ACS的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the association between rs3732378 single nucleotide polymorphism of chemokine CX3C receptor (CX3C receptor 1) CX3CR1 gene and acute coronary syndrome (ACS). Methods 951 cases of Han nationality in northern China were collected, including 520 males and 431 females aged 35 to 75 years. According to the results of coronary angiography (CAG), the patients were divided into two groups: the control group (n = 512) and the control group (n = 439). The patients were divided into three subgroups according to the number of branches of angiopathy examined by CAG. The genotypes of rs3732378 single nucleotide polymorphisms of CX3 CR1 gene were determined by sequencing. Multivariate logistic regression analysis was used to analyze the relationship between CX3CR1 gene rs3732378 polymorphism and risk of ACS. Enzyme linked immunosorbent assay (Elisa) was used to detect the expression of CX3C ligand 1 (CX3CL1) in plasma. Results there was no significant difference in genotype and allelic frequency of CX3CR1 gene rs3732378 between the two groups. The overall and stratified analysis of the polymorphic locus rs3732378 and the risk of CX3CR1 gene rs3732378 showed that neither TTTC nor CC of CX3CR1 gene rs3732378 polymorphism locus was found. It can increase the risk of ACS (P 0.05). Subgroup analysis showed that there was no correlation between genotype and allele of rs3732378 polymorphic locus and the number of coronary artery lesion branches (蠂 ~ 2 + 0.135), 蠂 ~ (2 +) = 0.026 (P = 0.987). There was no difference in CX3CL1 expression among the three genotypes of rs3732378 between the case group and the control group (P 0.05). Conclusion the polymorphism of rs3732378 polymorphism of CX3CR1 gene does not increase the risk of ACS in Han population in northern China.
【作者單位】： 錦州醫(yī)科大學(xué)研究生學(xué)院;沈陽(yáng)軍區(qū)總醫(yī)院心血管內(nèi)科;
【基金】：遼寧省科學(xué)技術(shù)計(jì)劃面上項(xiàng)目(2015020400)
【分類號(hào)】：R541.4
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本文編號(hào)：1999961