本文選題：還原性谷胱甘肽 + 糖尿病　； 參考：《臨床心血管病雜志》2017年12期

【摘要】：目的:探討還原型谷胱甘肽對(duì)糖尿病患者冠狀動(dòng)脈造影術(shù)后對(duì)比劑腎病(CIN)的預(yù)防作用。方法:選取我院2015-01-2016-06收治的糖尿病且擬行冠狀動(dòng)脈造影術(shù)和(或)經(jīng)皮冠狀動(dòng)脈介入術(shù)(PCI)的患者90例,采用前瞻性臨床對(duì)照研究的方法隨機(jī)分組為治療組(44例)和對(duì)照組(46例)。治療組給予還原型谷胱甘肽聯(lián)合水化治療,對(duì)照組僅給予水化治療,比較2組術(shù)前及術(shù)后72h腎功能指標(biāo)(血肌酐、血胱抑素C、腎小球?yàn)V過(guò)率)及CIN的發(fā)病率。結(jié)果:(1)術(shù)后72h,治療組患者血肌酐和血胱抑素水平顯著低于對(duì)照組[(89.5±18.4)μmol/L∶(99.5±20.4)μmol/L,P=0.016;(0.93±0.25)mg/L∶(1.18±0.33)mg/L,P=0.000 1],而腎小球?yàn)V過(guò)率則顯著高于對(duì)照組[(92.5±22.5)ml·min-1·1.73m~(-2)∶(82.7±23.5)ml·min-1·1.73m~(-2),P=0.045];(2)本研究中共9例患者診斷為CIN,總體發(fā)病率為10%。其中治療組和對(duì)照組CIN的發(fā)病率分別為2.33%和17.39%,差異有統(tǒng)計(jì)學(xué)意義(χ2=4.155,P=0.042)。結(jié)論:糖尿病患者行PCI診療后有較高的CIN發(fā)生風(fēng)險(xiǎn),而應(yīng)用還原型谷胱甘肽聯(lián)合水化療法可一定程度上降低糖尿病患者發(fā)生CIN的風(fēng)險(xiǎn)。
[Abstract]:Objective: to investigate the preventive effect of reduced glutathione on diabetic nephropathy after coronary angiography. Methods: ninety patients with diabetes mellitus undergoing coronary angiography and / or percutaneous coronary intervention were randomly divided into treatment group (n = 44) and control group (n = 46). The treatment group was treated with reduced glutathione combined with hydration, while the control group was only treated with hydration. The renal function indexes (serum creatinine, cystatin C, glomerular filtration rate) and the incidence of CIN were compared between the two groups before and 72 hours after operation. 緇撴灉:(1)鏈悗72h,娌葷枟緇勬?zhèn)ｈ�呰鑲岄厫鍜岃鑳辨姂绱犳按騫蟲(chóng)樉钁椾綆浜庡鐓х粍[(89.5鹵18.4)渭mol/L鈭，

本文編號(hào)：1918816