【摘要】：目的探討乳果糖口服液治療功能性便秘(FC)療效和安全性的系統(tǒng)評(píng)價(jià)。方法計(jì)算機(jī)檢索中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、中國(guó)科技期刊數(shù)據(jù)庫(kù)(維普網(wǎng))、中國(guó)知網(wǎng)(CNKI)和萬(wàn)方數(shù)據(jù)庫(kù),按入選患者的用藥不同,分為乳果糖組、對(duì)照組、聯(lián)合治療組,并對(duì)老年患者(年齡≥60歲)進(jìn)行亞組分析。對(duì)比三組臨床顯效率、總有效率、復(fù)發(fā)率以及不良反應(yīng)發(fā)生率。結(jié)果共納入10篇文獻(xiàn),累計(jì)FC患者1 069例,其中老年患者682例。Meta分析結(jié)果顯示乳果糖組總有效率達(dá)79.2%,與對(duì)照組相比有統(tǒng)計(jì)學(xué)差異(OR=7.14,95%CI為2.93~17.38)(P0.05)。聯(lián)合治療組的臨床顯效率和總有效率明顯優(yōu)于乳果糖組(OR=2.45,95%CI為1.56~3.83;OR=6.38,95%CI為2.99~13.63),且復(fù)發(fā)率低(P0.05)。老年乳果糖組的臨床療效優(yōu)于對(duì)照組,但同樣不及聯(lián)合治療組(P0.05)。乳果糖組的不良反應(yīng)發(fā)生率低,與對(duì)照組和聯(lián)合治療組相比,差異均無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05),在老年患者中亦無(wú)增加趨勢(shì)(P0.05)。結(jié)論乳果糖口服液治療FC的療效較好且安全,以乳果糖為基礎(chǔ)的聯(lián)合治療更優(yōu)于單藥治療,尤其適合老年FC患者。
[Abstract]:Objective to evaluate the efficacy and safety of lactulose oral liquid in the treatment of functional constipation (FC). Methods the Chinese biomedical literature database, (CBM), (CNKI) and Wanfang database were searched by computer. They were divided into lactose group and control group according to the different drugs used by the selected patients, and the patients were divided into two groups: lactose group and control group, and the control group was divided into two groups: lactose group and control group. Combined treatment group, and the elderly patients (age 鈮，

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