【摘要】：目的:觀察莫沙比利聯(lián)合氟哌噻噸美利曲辛治療老年人功能性燒心的臨床療效及安全性。方法:選取診斷符合"羅馬Ⅲ"標準、確診為功能性燒心的老年患者106例,按隨機數字表法分為對照組(52例)和治療組(54例)。對照組給予口服枸櫞酸莫沙比利分散片5 mg,tid;治療組在對照組的基礎上,加服氟哌噻噸美利曲辛片(含氟哌噻噸0.5mg和美利曲辛10mg),qd,4周后觀察療效。兩組患者治療前后均給予漢密爾頓焦慮量表(HAMA)、漢密爾頓抑郁量表(HAMD)評分及癥狀學積分。結果:治療組總有效率87.0%,對照組總有效率為53.8%,差異有統(tǒng)計學意義(P0.05);兩組患者治療后癥狀學積分、HAMA評分、HAMD評分差異均有統(tǒng)計學意義(P0.01);兩組患者均未發(fā)現嚴重不良反應。結論:莫沙比利聯(lián)合氟哌噻噸美利曲辛治療老年人功能性燒心安全、有效。
[Abstract]:Objective: to observe the clinical efficacy and safety of mosapride combined with flupentametaxine in the treatment of functional heartburn in the elderly. Methods: 106 elderly patients with functional heartburn were randomly divided into control group (n = 52) and treatment group (n = 54). The control group was treated with mosapride citrate dispersible tablet 5mg, and the tid; treatment group was treated with dropermethorphan meretaxine tablets (containing 0.5mg and meretaxine) for 10 mg), qd,4 weeks to observe the therapeutic effect of the treatment group on the basis of the control group. The patients in both groups were given Hamilton anxiety scale (HAMA), Hamilton Depression scale (HAMD) score and symptom score before and after treatment. Results: the total effective rate was 87.0% in the treatment group and 53.8% in the control group, the difference was statistically significant (P0.05), and there were significant differences in symptom score, HAMA score and HAMD score between the two groups after treatment (P0.01). No serious adverse reactions were found in both groups. Conclusion: mosapride combined with dropethiam meretaxine is safe and effective in the treatment of elderly patients with functional heartburn.
【作者單位】： 溫州醫(yī)科大學附屬第六醫(yī)院;麗水市人民醫(yī)院消化內科;
【分類號】：R571

【相似文獻】

相關期刊論文 前7條

1 石碧堅,劉厚鈺;功能性燒心[J];胃腸病學和肝病學雜志;2002年04期

2 趙立英;;丹梔逍遙丸加減治療功能性燒心20例[J];山東中醫(yī)雜志;2010年08期

3 李舟文;謝彥鵬;梁益輝;許能欽;;精神心理因素對功能性燒心生活質量的影響[J];衛(wèi)生職業(yè)教育;2012年05期

4 易智慧;楊正兵;馮麗;文茂瑤;楊麗;;功能性燒心與功能性消化不良、腸易激綜合征癥狀重疊研究[J];四川大學學報(醫(yī)學版);2014年03期

5 辛海威;方秀才;柯美云;;燒心 反酸 胸骨后疼痛[J];中國實用內科雜志;2011年12期

6 孫濤;功能性燒心和胃食管反流病的藥物治療[J];中華內科雜志;2000年08期

7 ;[J];;年期

相關會議論文 前2條

1 張艷麗;柯美云;方秀才;孫曉紅;王智鳳;;功能性燒心患者精神心理異常、食管酸高敏和自主神經功能的評價[A];中華醫(yī)學會第七次全國消化病學術會議論文匯編（上冊）[C];2007年

2 陶金;肖英蓮;陳曼湖;彭穗;林金坤;熊理守;胡品津;;功能性燒心患者食管黏膜上皮細胞間隙的變化[A];中華醫(yī)學會第七次全國消化病學術會議論文匯編（上冊）[C];2007年

，

本文編號：2443939