【摘要】：目的探討低分子右旋糖酐聯(lián)合吲哚美辛栓劑對內(nèi)鏡逆行胰膽管造影術(ERCP)后胰腺炎的預防作用。方法 215例至少具備一項ERCP術后胰腺炎高危因素的患者術前隨機分為四組。對照組(n=51)給予氯化鈉注射液+安慰劑,吲哚美辛組(n=54)給予氯化鈉注射液+吲哚美辛栓劑(術前單次經(jīng)直腸給藥50 mg),低分子右旋糖酐組(n=52)給予低分子右旋糖酐(術前單次靜脈輸注500 m L)+安慰劑,藥物聯(lián)用組(n=58)給予低分子右旋糖酐(術前單次靜脈輸注500 m L)+吲哚美辛栓劑(術前單次經(jīng)直腸給藥50 mg)。觀察術后胰腺炎發(fā)生率、重癥急性胰腺炎發(fā)生率及患者死亡率,記錄住院時間。結果對照組、吲哚美辛組、低分子右旋糖酐組和藥物聯(lián)用組胰腺炎發(fā)生率分別為24%、15%、14%和5%,藥物聯(lián)用組ERCP術后胰腺炎發(fā)生率低于對照組(P0.01);四組患者重癥胰腺炎發(fā)生率以及死亡率無顯著差異(P0.05)。對照組、吲哚美辛組、低分子右旋糖酐組和藥物聯(lián)用組平均住院時間分別為(5.8±2.9)、(5.2±1.9)、(6.1±2.5)和(4.3±2.0)d,與其他三組相比,藥物聯(lián)用組術后平均住院時間縮短(P0.05)。結論低分子右旋糖酐聯(lián)合吲哚美辛栓劑對于ERCP術后胰腺炎有較好的預防作用。
[Abstract]:Objective to investigate the preventive effect of low molecular dextran and indomethacin suppository on pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Methods 215 patients with at least one risk factor of pancreatitis after ERCP were randomly divided into four groups. The control group (nf51) was given a placebo of sodium chloride injection. Indomethacin group (nnt54) was treated with sodium chloride injection indomethacin suppository (50 mg), before rectal administration) and low-molecular-weight dextran group (nf52) with low molecular weight dextran (500ml intravenously before operation) as a placebo. The combined drug group (nong58) was given low-molecular-weight dextran (500ml intravenously before operation) with indomethacin suppository (50 mg). Before single transrectal administration). The incidence of postoperative pancreatitis, the incidence of severe acute pancreatitis and the mortality of patients were observed, and the hospitalization time was recorded. Results the control group, indomethacin group, The incidence of pancreatitis in the low molecular dextran group and the combined drug group was 24 15% and 5%, respectively. The incidence of ERCP postoperative pancreatitis in the combined drug group was lower than that in the control group (P0.01), but there was no significant difference in the incidence and mortality of severe pancreatitis among the four groups (P0.05). The average hospitalization time of control group, indomethacin group, low molecular weight dextran group and drug combination group were (5.8 鹵2.9), (5.2 鹵1.9), (6.1 鹵2.5) days and (4.3 鹵2.0) days, respectively. Compared with the other three groups, the average hospitalization time of the combined drug group was shorter than that of the other three groups (P0.05). Conclusion low-molecular dextran combined with indomethacin suppository can prevent pancreatitis after ERCP.
【作者單位】： 重慶醫(yī)科大學附屬第一醫(yī)院第一分院消化內(nèi)科;重慶醫(yī)科大學附屬第一醫(yī)院消化內(nèi)科;
【分類號】：R576

【相似文獻】

相關期刊論文 前10條

1 鄧yN;小劑量尿激酶加低分子右旋糖酐治療急性出血壞死性胰腺炎[J];醫(yī)藥論壇雜志;2004年01期

2 張美真;低分子右旋糖酐治療急性水腫型胰腺炎15例臨床分析[J];浙江中西醫(yī)結合雜志;1996年02期

3 游旭東,馬新橋;甘露醇、低分子右旋糖酐治療肝硬化頑固性腹水的療效評價[J];中原醫(yī)刊;2003年14期

4 張建,徐永居;低分子右旋糖酐治療急性水腫型胰腺炎30例臨床觀察[J];寧夏醫(yī)學雜志;1999年02期

5 張新杰;低分子右旋糖酐加多巴胺在急性水腫型胰腺炎中的療效觀察[J];中原醫(yī)刊;2004年08期

6 孫錫波 ,張銀華 ,牛建霞 ,房顯增;低分子右旋糖酐靜脈滴注結合多巴胺與速尿腹腔內(nèi)注射治療肝硬變頑固性腹水[J];中國綜合臨床;2002年09期

7 施友明,蔣榮林;低分子右旋糖酐、復合丹參、多巴胺靜脈滴注治療肝性腹水32例[J];中國廠礦醫(yī)學;2002年02期

8 向開敏;王學鋒;李皇保;;地塞米松和低分子右旋糖酐單用及聯(lián)合使用治療急性胰腺炎的療效對比[J];中國全科醫(yī)學;2010年26期

9 林映川,吳冬寒;低分子右旋糖酐加速尿治療肝硬化頑固性腹水的療效觀察[J];海南醫(yī)學;2001年05期

10 殷衛(wèi)衛(wèi);前列腺素E_1聯(lián)合低分子右旋糖酐治療肝硬化難治性腹水[J];中國基層醫(yī)藥;2005年02期

相關會議論文 前1條

1 鄧鉞濤;余永歡;鄧小榮;李濤;戴安邦;胡家平;;大黃和低分子右旋糖酐治療急性胰腺炎43例的應用體會[A];中華醫(yī)學會第10屆全國胰腺外科學術研討會論文匯編[C];2004年

，

本文編號：2131752