發(fā)布時(shí)間：2018-06-27 12:41

  本文選題：PICI% + 肝硬化��； 參考：《廣東醫(yī)學(xué)》2016年10期

【摘要】：目的研究常規(guī)凝血指標(biāo)在肝硬化患者的變化,探討蛇毒誘導(dǎo)凝固抑制試驗(yàn)(PICI%)在判斷肝硬化凝血狀態(tài)的臨床價(jià)值。方法收集肝硬化患者236例,正常對(duì)照組90例。均進(jìn)行凝血酶原時(shí)間(PT)、活化部分凝血活酶時(shí)間(APTT)、PICI%的檢測(cè)。結(jié)果 (1)肝硬化患者的PT明顯高于對(duì)照組(P0.01),隨病情加重逐漸延長(zhǎng),而PICI%明顯低于對(duì)照組(P0.01),隨肝功能分級(jí)變差逐漸降低,且兩指標(biāo)在對(duì)照組、Child-Pugh A、B、C間兩兩比較差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。(2)PICI%與PT呈負(fù)相關(guān),且相關(guān)關(guān)系密切(相關(guān)系數(shù)r=0.649,P0.01)。結(jié)論 PICI%能夠有效反映肝硬化患者的高凝狀態(tài),可作為臨床準(zhǔn)確判斷肝硬化出血或血栓的指標(biāo)。PT、PICI%均可作為臨床評(píng)估肝硬化患者病情進(jìn)展及預(yù)后的指標(biāo)。
[Abstract]:Objective to study the changes of routine coagulation parameters in patients with liver cirrhosis and to explore the clinical value of snake venom induced coagulation inhibition test (PICI%) in judging the coagulation state of cirrhosis. Methods 236 cirrhotic patients and 90 normal controls were collected. Prothrombin time (PT), activated partial thromboplastin time (APTT) and PICI% were measured. Results (1) PT of patients with liver cirrhosis was significantly higher than that of the control group (P0.01), and the PICI% was significantly lower than that of the control group (P0.01). There was a negative correlation between PICI% and PT in the control group (P 0.01). (2), and there was a close correlation between the two indexes (r = 0. 649%, P 0. 01). Conclusion PICI% can effectively reflect the hypercoagulable state of the patients with liver cirrhosis and can be used as a clinical accurate index to judge the bleeding or thrombus in cirrhosis. PICI% can be used as an index to evaluate the progression and prognosis of the patients with liver cirrhosis.
【作者單位】： 廣州醫(yī)科大學(xué)附屬?gòu)V州市第一人民醫(yī)院消化科、廣州消化疾病研究所;廣東省廣州市第八人民醫(yī)院消化科;廣州醫(yī)科大學(xué)附屬第二醫(yī)院消化科;
【基金】：廣東省廣州市胃腸病醫(yī)學(xué)研究與轉(zhuǎn)化中心資助項(xiàng)目(編號(hào):201508020001)
【分類號(hào)】：R575.2
，

本文編號(hào)：2073952