發(fā)布時間：2018-03-16 14:32

  本文選題：普洱茶　切入點：非酒精性脂肪性肝病　出處：《茶葉科學》2016年03期 　論文類型：期刊論文

【摘要】：研究了普洱茶調控非酒精性脂肪肝大鼠腸道對長鏈脂肪酸的吸收,并探討了其可能機制。將36只SD大鼠隨機分成正常對照組、脂肪肝模型組和普洱茶干預組,每組12只。實驗第8周末處死所有大鼠,測定大鼠體質量、肝指數(shù)及血清血脂水平;采用定量PCR測定大鼠腸道黏膜脂質吸收相關蛋白細胞分化抗原36(Cluster of differentiation 36,CD36)、緊密連接相關蛋白如閉鎖蛋白(Occludin)、緊密連接蛋白(Zonula occludens 1,ZO-1)和腫瘤壞死因子α(Tumor necrosis factor-α,TNF-α)基因表達水平。研究結果表明,與模型組相比,普洱茶組大鼠體質量和血清LDL-C水平分別下降了16.12%和42.59%;此外,普洱茶組大鼠小腸組織CD36、TNF-α表達水平明顯降低,而Occludin、ZO-1表達水平明顯升高。研究發(fā)現(xiàn),普洱茶對NAFLD大鼠腸道長鏈脂肪酸吸收及腸道緊密連接蛋白有一定程度的調控作用,尤其是對NAFLD早期發(fā)生發(fā)展中游離脂肪酸過度沉積的"第一次打擊"有防治價值。
[Abstract]:The regulation of Pu'er tea on the absorption of long chain fatty acids in the intestine of rats with non-alcoholic fatty liver was studied, and the possible mechanism was discussed. 36 SD rats were randomly divided into three groups: normal control group, fatty liver model group and Pu'er tea intervention group. At the end of the 8th week, all the rats were killed and the body mass, liver index and serum lipids were measured. Quantitative PCR was used to determine the gene expression of rat intestinal mucosal lipids absorption-associated protein cell differentiation antigen 36 of differentiation 36, tightly linked proteins such as Occludinia, Zonula occludens 1ZO-1 and tumor necrosis factor 偽 tumor necrosis factor- 偽 (TNF- 偽) gene expression in rat intestinal mucosal lipid absorption associated protein (LAPs), including close-ligated proteins such as Occludinia, Zonula occludens 1, ZO-1) and tumor necrosis factor 偽 Tumor necrosis factor- 偽 (TNF- 偽). ... the results of the study show that. Compared with the model group, the body weight and serum LDL-C level of Pu'er tea group decreased by 16.12% and 42.59, respectively, in addition, the expression of CD36 TNF- 偽 in small intestine of Pu'er tea group decreased significantly, while the expression level of Occludingnan ZO-1 increased significantly in Pu'er tea group. Pu'er tea can regulate the absorption of long chain fatty acids and tight junction protein in intestinal tract of NAFLD rats to a certain extent, especially for the "first strike" of excessive deposition of free fatty acids in the early stage of NAFLD.
【作者單位】： 浙江大學醫(yī)學院附屬第二醫(yī)院;農業(yè)部茶樹生物學與資源利用重點實驗室中國農業(yè)科學院茶葉研究所;
【基金】：中醫(yī)藥重點研究計劃(2012ZZ011)
【分類號】：TS272.54;R575.5

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