本文關(guān)鍵詞：CRP、PCT、pANCA與炎癥性腸病的相關(guān)性研究　出處：《新疆醫(yī)科大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

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【摘要】：目的:探討C反應(yīng)蛋白(CRP)、降鈣素原(PCT)、核周型抗中性粒細(xì)胞胞漿抗體(pANCA)在炎癥性腸病(IBD)中的臨床價(jià)值。方法:本研究共納入IBD患者67例,潰瘍性結(jié)腸炎(UC)患者45例,克羅恩病(CD)患者22例,在健康人群中選取20名作為對(duì)照組。分別用免疫層析法檢測(cè)CRP和PCT,酶聯(lián)免疫吸附法(ELISA)檢測(cè)pANCA,比較UC、CD和健康對(duì)照組血清CRP、PCT、pANCA水平的差異性。評(píng)估CRP、PCT、pANCA與UC、CD疾病活動(dòng)性的關(guān)系,并通過聯(lián)合檢測(cè)了解三者對(duì)IBD的診斷意義。結(jié)果:血清CRP、PCT、pANCA水平在UC組、CD組及健康對(duì)照組中均存在顯著差異,P均0.05。CD組血清CRP水平高于UC組,差異有統(tǒng)計(jì)學(xué)意義。CD組與UC組血清PCT水平不存在顯著差異,P=0.4630.05。UC組pANCA陽性率(53.3%)高于CD組(18.2%),P=0.0130.0167,差異有統(tǒng)計(jì)學(xué)意義。CRP、PCT水平與IBD疾病活動(dòng)度呈正相關(guān),pANCA可以預(yù)測(cè)UC活動(dòng)度,而對(duì)CD診斷意義不大。聯(lián)合檢測(cè)CRP、PCT和pANCA可以提高診斷的靈敏度。結(jié)論:血清CRP、PCT、pANCA水平在IBD和健康對(duì)照組中存在顯著差異,對(duì)UC、CD有診斷和鑒別診斷意義,CRP、PCT與IBD活動(dòng)度相關(guān),pANCA可以預(yù)測(cè)UC活動(dòng)度,左半結(jié)腸UC患者pANCA陽性率較高。
[Abstract]:Objective: to study the C-reactive protein (CRP) and procalcitonin (PCT). Clinical value of peripheral anti-neutrophil cytoplasmic antibody (pANCA) in inflammatory bowel disease (IBD). Methods: 67 patients with IBD were included in this study. 45 patients with ulcerative colitis and 22 patients with Crohn's disease were selected as control group. CRP and PCT were detected by immunochromatography. Elisa was used to detect pANCA, to compare the difference of serum levels of CRPT-pANCA between UCG-CD and healthy controls, and to evaluate the level of CRPc-PCT. The relationship between the activity of pANCA and the disease activity of UCG-CD and the diagnostic significance of the three methods to IBD by combined detection. Results: the level of serum CRPP-PCTpANCA was found in UC group. There were significant differences between CD group and healthy control group (P < 0.05). The serum CRP level in CD group was higher than that in UC group. There was no significant difference in serum PCT level between CD group and UC group. The positive rate of pANCA in the group of 0.4630.05.UC was higher than that in the group of CD (0.0130.0167), the difference was statistically significant. There was a positive correlation between PCT level and disease activity of IBD. PANCA could predict UC activity, but had little significance for CD diagnosis. PCT and pANCA can improve the sensitivity of diagnosis. Conclusion: there is a significant difference between IBD and healthy control group in the level of serum CRPP-PCT pANCA. CD has diagnostic and differential diagnostic significance. The correlation between CRPCT and IBD activity can predict UC activity, and the positive rate of pANCA in UC patients with left hemicolon is higher.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R574.62

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1 王志遠(yuǎn);CRP、PCT、pANCA與炎癥性腸病的相關(guān)性研究[D];新疆醫(yī)科大學(xué);2016年

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