【摘要】：目的探討鼓室注射地塞米松對老年分泌性中耳炎(SOM)激素骨膜穿刺術患者血清炎性因子、免疫功能及聽力恢復的影響。方法老年SOM患者146例,采用隨機數(shù)字表法分為觀察組和對照組各73例。對照組采取鼓膜穿刺術治療,觀察組采取鼓膜穿刺術聯(lián)合鼓室注射糖皮質(zhì)激素治療,比較兩組血清炎性因子、免疫功能、聽覺閾值、臨床療效。結(jié)果治療1個月后,觀察組有效率明顯高于對照組(χ~2=10.860,P0.01);血清內(nèi)皮素(ET)-1、腫瘤壞死因子(TNF)-α、γ-干擾素(INF-γ)含量明顯低于對照組(P0.05);T淋巴細胞亞群CD3~+、CD4~+、CD4~+/CD8~+均明顯高于對照組(P0.05);500、1 000、2 000 Hz等聽閾值明顯低于對照組(P0.001)。結(jié)論鼓室注射地塞米松有助于緩解老年SOM彭膜穿刺術患者血清炎性因子表達水平,改善免疫功能,提高聽力水平。
[Abstract]:Objective to investigate the effect of tympanic injection of dexamethasone on serum inflammatory factors, immune function and hearing recovery in elderly patients with secretory otitis media treated with (SOM) hormone periosteum puncture. Methods 146 elderly patients with SOM were randomly divided into observation group (n = 73) and control group (n = 73). The control group was treated with tympanic membrane puncture, and the observation group was treated with tympanic membrane puncture combined with tympanic injection of glucocorticoid. The serum inflammatory factors, immune function, auditory threshold and clinical efficacy were compared between the two groups. Results after one month of treatment, the effective rate in the observation group was significantly higher than that in the control group (蠂 ~ 2 鈮，

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