【摘要】：目的：通過研究阻塞性睡眠呼吸暫停綜合征(Obstructive Sleep Apnea Syndrome, OSAS)患者血清中白介素-18(IL-18)和單核細(xì)胞趨化蛋白-1(MCP-1)水平變化,探討IL-18和MCP-1在OSAS中的作用。 方法：選擇來我院就診的56例OSAS患者和25例健康人,分別作為實(shí)驗(yàn)組和對(duì)照組。分別測(cè)定實(shí)驗(yàn)組患者術(shù)前、術(shù)后和對(duì)照組的血清中IL-18和MCP-1的水平及其他一般情況(睡眠呼吸暫停低通氣指數(shù)、最低動(dòng)脈血氧飽和度、收縮壓、舒張壓、脈壓差)的變化。 結(jié)果：(1)OSAS患者的脈壓差明顯高于對(duì)照組,且隨著OSAS的患病程度加重脈壓差逐漸增高；OSAS患者脈壓差的增高與IL-18和MCP-1水平增高密切相關(guān)。(2)OSAS患者血清中IL-18和MCP-1的水平遠(yuǎn)遠(yuǎn)高于健康人,且OSAS的患病嚴(yán)重程度與IL-18和MCP-1水平密切相關(guān),同時(shí)IL-18和MCP-1之間存在線性關(guān)系；(3)OSAS患者經(jīng)過手術(shù)治療后血清中IL-18和MCP-1含量較術(shù)前明顯下降。 結(jié)論：(1)OSAS患者得心血管疾病的風(fēng)險(xiǎn)明顯高于正常人,且隨著OSAS病情的嚴(yán)重程度,患心血管疾病的風(fēng)險(xiǎn)越大,其機(jī)制可能與血清中IL-18和MCP-1水平的增高密切相關(guān)。(2)血清中IL-18和MCP-1的水平與OSAS的發(fā)病密切相關(guān),并且直接反應(yīng)了OSAS病情的嚴(yán)重程度。
[Abstract]:Objective: to study the changes of serum levels of interleukin-18 (IL-18) and monocyte chemoattractant protein-1 (MCP-1) in patients with obstructive sleep apnea syndrome (Obstructive Sleep Apnea Syndrome, OSAS). To explore the role of IL-18 and MCP-1 in OSAS. Methods: 56 patients with OSAS and 25 healthy persons were selected as experimental group and control group. The serum levels of IL-18 and MCP-1 were measured before, after operation and in the control group (sleep apnea hypopnea index, minimum arterial oxygen saturation, systolic blood pressure, diastolic blood pressure), and other general conditions (sleep apnea hypopnea index, minimum arterial oxygen saturation, systolic blood pressure, diastolic blood pressure). Pulse pressure difference). Results: (1) the pulse pressure difference of OSAS patients was significantly higher than that of the control group, and gradually increased with the severity of OSAS. The increase of pulse pressure difference in OSAS patients was closely related to the increase of IL-18 and MCP-1 levels. (2) the levels of IL-18 and MCP-1 in the serum of OSAS patients were much higher than those of healthy people, and the severity of OSAS was closely related to the levels of IL-18 and MCP-1. At the same time, there is a linear relationship between IL-18 and MCP-1. (3) the levels of IL-18 and MCP-1 in serum of OSAS patients were significantly lower than those before operation. Conclusion: (1) the risk of cardiovascular disease in OSAS patients is significantly higher than that in normal controls, and the risk of cardiovascular disease increases with the severity of OSAS. The mechanism may be closely related to the increase of IL-18 and MCP-1 in serum. (2) the levels of IL-18 and MCP-1 in serum are closely related to the pathogenesis of OSAS and directly reflect the severity of OSAS.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R766

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