康柏西普對濕性年齡相關(guān)性黃斑變性患者脈絡(luò)膜厚度及睫狀后動脈血流的影響
發(fā)布時間：2018-10-08 15:10
【摘要】：目的探討康柏西普對濕性年齡相關(guān)性黃斑變性(AMD)患者脈絡(luò)膜厚度及睫狀后動脈血流的影響。方法濕性AMD患者100例,根據(jù)給藥方式不同分為康柏西普組和曲安奈德組各50例。曲安奈德組給予曲安奈德0.1 ml注射,康柏西普組給予康柏西普0.05 ml注射,采用高頻多普勒超聲測量患者治療眼的睫狀后動脈血流動力學(xué)參數(shù),包括收縮期峰值流速(PSV)、舒張末期血流速度(EDV)、阻力指數(shù)(RI),采用Spectralis光學(xué)相干斷層掃描(OCT)的EDI技術(shù)測量中心凹下脈絡(luò)膜厚度(SFCT),對比分析兩組治療前后睫狀后動脈PSV、EDV、RI、SFCT及不良反應(yīng)。結(jié)果康柏西普組治療后1、4、8 w SFCT明顯低于曲安奈德組(P0.05);兩組均無出現(xiàn)眼壓增高、眼內(nèi)炎、白內(nèi)障、視網(wǎng)膜脫離等不良反應(yīng)。結(jié)論濕性AMD患者注射康柏西普能更有效降低患者脈絡(luò)膜厚度,改善睫狀后動脈血流,促進(jìn)疾病恢復(fù),安全可靠。
[Abstract]:Objective to investigate the effect of Compactopril on choroidal thickness and blood flow of posterior ciliary artery in patients with wet age related macular degeneration (AMD). Methods 100 patients with wettable AMD were divided into two groups according to different administration methods: Compactopril group and triamcinolone acetonide group. The triamcinolone acetonide group was injected with triamcinolone acetonide 0. 1 ml, and the Compactopril group was injected with Compactopril 0. 05 ml. The hemodynamic parameters of the posterior ciliary artery were measured by high frequency Doppler ultrasound in the eyes treated with triamcinolone acetonide. Including peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI),) Spectralis optical coherence tomography (OCT) EDI technique was used to measure the thickness of subcentral foveal choroid by (SFCT), comparison analysis of PSV,EDV,RI,SFCT and adverse reactions of posterior ciliary artery before and after treatment in two groups. Results the SFCT was significantly lower in Compactopril group than that in triamcinolone acetonide group at 8 weeks after treatment (P0.05), and no adverse reactions such as intraocular pressure elevation, endophthalmitis, cataract and retinal detachment were found in both groups. Conclusion injection of Compactopril in wet AMD patients can reduce the choroidal thickness, improve the blood flow of the posterior ciliary artery, promote the recovery of the disease, and be safe and reliable.
【作者單位】： 海南醫(yī)學(xué)院附屬第二醫(yī)院;
【分類號】：R774.5
本文編號：2257231
[Abstract]:Objective to investigate the effect of Compactopril on choroidal thickness and blood flow of posterior ciliary artery in patients with wet age related macular degeneration (AMD). Methods 100 patients with wettable AMD were divided into two groups according to different administration methods: Compactopril group and triamcinolone acetonide group. The triamcinolone acetonide group was injected with triamcinolone acetonide 0. 1 ml, and the Compactopril group was injected with Compactopril 0. 05 ml. The hemodynamic parameters of the posterior ciliary artery were measured by high frequency Doppler ultrasound in the eyes treated with triamcinolone acetonide. Including peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI),) Spectralis optical coherence tomography (OCT) EDI technique was used to measure the thickness of subcentral foveal choroid by (SFCT), comparison analysis of PSV,EDV,RI,SFCT and adverse reactions of posterior ciliary artery before and after treatment in two groups. Results the SFCT was significantly lower in Compactopril group than that in triamcinolone acetonide group at 8 weeks after treatment (P0.05), and no adverse reactions such as intraocular pressure elevation, endophthalmitis, cataract and retinal detachment were found in both groups. Conclusion injection of Compactopril in wet AMD patients can reduce the choroidal thickness, improve the blood flow of the posterior ciliary artery, promote the recovery of the disease, and be safe and reliable.
【作者單位】： 海南醫(yī)學(xué)院附屬第二醫(yī)院;
【分類號】：R774.5
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