本文選題：口咽癌 + 鱗狀細(xì)胞癌�。� 參考：《現(xiàn)代腫瘤醫(yī)學(xué)》2016年04期

【摘要】：目的:研究口咽鱗癌(oropharyngeal squamous cell carcinomas,OSCC)中人乳頭瘤病毒(human papillomavirus,HPV)感染與血管內(nèi)皮生長(zhǎng)因子(vascular endothelial growth factor,VEGF)、CD31標(biāo)記的微血管密度(microvessel density,MVD)表達(dá)的關(guān)系,探討它們?cè)诳谘树[癌發(fā)生中的相互關(guān)系。方法:采用多重實(shí)時(shí)熒光定量聚合酶鏈反應(yīng)(multiplex real-time polymerase chain reaction,MT-PCR)檢測(cè)60例口咽鱗癌HPV DNA及型別,通過(guò)HPV DNA分析進(jìn)行HPV感染狀況的測(cè)定;同時(shí)采用半定量免疫組化檢測(cè)HPV(+)組和HPV(-)組中VEGF、CD31(MVD標(biāo)志)蛋白表達(dá)情況。結(jié)果:口咽鱗癌中HPV感染率36.7%(22/60),HPV-16型占所有感染者的比例86.4%(19/22),明顯高于其他型別;VEGF高度表達(dá)者出現(xiàn)MVD15個(gè)/高倍視野的幾率較VEGF低度表達(dá)者高(P=0.001);MVD15個(gè)/高倍視野的腫瘤為低分化的可能性較高(P=0.004);VEGF和MVD表達(dá)與患者年齡、性別、TNM分期、HPV感染狀況之間無(wú)相關(guān)性。結(jié)論:HPV感染與口咽鱗癌的發(fā)生存在相關(guān)性�？谘树[癌中HPV感染狀況和VEGF之間無(wú)相關(guān)性。
[Abstract]:Objective: to investigate the relationship between human papillomavirus infection and the expression of CD31 labeled microvessel density in oropharyngeal squamous cell carcinoma (OSCC), and to explore the relationship between human papillomavirus infection and CD31 labeled microvessel density in oropharyngeal squamous cell carcinoma (OSCC). Methods: multiplex real-time fluorescent quantitative polymerase chain reaction (MT-PCR) was used to detect HPVDNA and its types in 60 patients with oropharyngeal squamous cell carcinoma (OSCC). The expression of VEGF CD31 (MVD marker) in HPV (-) and HPV (-) groups was detected by semi-quantitative immunohistochemistry. Results: in oropharyngeal squamous cell carcinoma, HPV infection rate was 36.7% (22 / 60) and HPV-16 accounted for 86.4% (19 / 22) of all infected patients, which was significantly higher than that of other types of high expression VEGF with 15 MVD15 / high power visual fields than those with low VEGF expression (P0. 001). The expression of VEGF and MVD was more likely to be differentiated (P0. 004) and the expression of VEGF and MVD was associated with the age of the patients. There was no correlation between sex TNM staging and HPV infection. Conclusion there is a correlation between the infection of human papillomavirus (HPV) and the occurrence of oropharyngeal squamous cell carcinoma. There was no correlation between HPV infection and VEGF in oropharyngeal squamous cell carcinoma.
【作者單位】： 昆明醫(yī)科大學(xué)第三附屬醫(yī)院云南省腫瘤醫(yī)院頭頸外科;昆明醫(yī)科大學(xué);昆明醫(yī)科大學(xué)第三附屬醫(yī)院云南省腫瘤醫(yī)院病理科;
【基金】：留學(xué)人員科技活動(dòng)項(xiàng)目擇優(yōu)資助基金資助項(xiàng)目(云南省2010年度啟動(dòng)類)
【分類號(hào)】：R739.63

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 靖衛(wèi)霞;侯秀娟;孫文燕;馬濤;王新祥;朱躍蘭;;溫經(jīng)通絡(luò)法對(duì)CIA大鼠關(guān)節(jié)滑膜組織VEGF及其受體基因表達(dá)的影響[J];北京中醫(yī)藥;2014年03期

2 胡靜嫻;樊曉明;;結(jié)腸直腸癌靶向治療的現(xiàn)狀及進(jìn)展[J];世界臨床藥物;2015年06期

3 王璐;陳芳;徐志波;陳彬;何薇;胡敬獻(xiàn);張麗婷;劉賢忠;;保肺定喘湯對(duì)COPD大鼠氣道重塑中VEGF及受體R1、R2的影響[J];中華中醫(yī)藥雜志;2015年10期

4 靖衛(wèi)霞;朱躍蘭;侯秀娟;王華新;;血管內(nèi)皮生長(zhǎng)因子與類風(fēng)濕關(guān)節(jié)炎的相關(guān)性研究[J];現(xiàn)代中醫(yī)臨床;2014年01期

5 伍婷婷;黃新次;葉鳳;張百芳;;高濃度葡萄糖誘導(dǎo)大鼠腎小球系膜細(xì)胞VEGF的表達(dá)上調(diào)依賴于PKCβⅠ和RhoA的活化[J];武漢大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2015年02期

6 張文天;連鋒;薛松;;胎盤生長(zhǎng)因子在心肌梗死后的心肌再生治療中的研究進(jìn)展[J];上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2014年10期

7 劉賢忠;張麗婷;童衛(wèi)泉;王帥;徐志波;陳芳;;貝伐單抗在肺癌中的研究進(jìn)展[J];中國(guó)全科醫(yī)學(xué);2015年09期

8 高秋蓮;梅湘;陳俞池;楊德乾;高永翔;;中醫(yī)藥抑制類風(fēng)濕關(guān)節(jié)炎血管翳形成的研究概況[J];中醫(yī)藥學(xué)報(bào);2013年05期

9 Inês Marques;António Araújo;Ramon Andrade de Mello;;Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives[J];World Journal of Gastroenterology;2013年44期

10 丁曉潔;李多;黃新偉;付娟娟;潘s，

本文編號(hào)：2078951