發(fā)布時間：2018-01-20 00:36

  本文關鍵詞： 鼻咽癌 促血管生成素1 促血管生成素2 受體Tie-2　出處：《桂林醫(yī)學院》2012年碩士論文　論文類型：學位論文

【摘要】：目的：初步探討Ang-1和Ang-2及其受體Tie-2在鼻咽癌患者血循環(huán)中的水平及其臨床意義。 方法：應用酶聯(lián)免疫吸附試驗檢測20例健康對照者及68例鼻咽癌患者(初治32例,復發(fā)16例,完全緩解20例)血清Ang-1和Ang-2及其受體Tie-2水平。 結果：初治組和復發(fā)組鼻咽癌患者血清Ang-1和Ang-2及其受體Tie-2的水平均高于完全緩解組及健康對照組(P0.01),而這些分子的含量在完全緩解組和健康對照組比較無明顯差異(P0.05)。Ang-2及Tie-2的水平在鼻咽癌患者不同T分期、臨床分期比較有統(tǒng)計學意義(P0.05),并隨著鼻咽癌進展呈上升趨勢；Ang-1水平在不同T分期、臨床分期比較差異無統(tǒng)計學意義(P0.05)；在不同N分期,Ang-2水平比較有統(tǒng)計學意義(P0.05)。轉移鼻咽癌患者血清Ang-2及Tie-2水平明顯高于無轉移組(P0.01)。Ⅰ+Ⅱ期鼻咽癌患者血清Ang-1/Ang-2比值高于Ⅲ+Ⅳa期(P0.01) 結論：Ang-1和Ang-2及其受體Tie-2在鼻咽癌的發(fā)生發(fā)展過程中起重要作用,并與腫瘤的侵襲轉移有密切關系。
[Abstract]:Objective: to investigate the level and clinical significance of Ang-1, Ang-2 and its receptor Tie-2 in the blood circulation of patients with nasopharyngeal carcinoma (NPC). Methods: enzyme linked immunosorbent assay (Elisa) was used to detect 20 healthy controls and 68 nasopharyngeal carcinoma patients (32 cases of primary treatment and 16 cases of recurrence). The levels of serum Ang-1, Ang-2 and their receptor Tie-2 in 20 patients with complete remission. Results: the levels of serum Ang-1, Ang-2 and their receptor Tie-2 in nasopharyngeal carcinoma patients were higher than those in complete remission group and healthy control group (P 0.01). However, there was no significant difference in the content of these molecules between the complete remission group and the healthy control group. The levels of P0.05U. Ang-2 and Tie-2 in patients with nasopharyngeal carcinoma at different T stages. The clinical staging was statistically significant (P 0.05), and increased with the progression of nasopharyngeal carcinoma (NPC). There was no significant difference in Ang-1 levels between different T stages and clinical stages (P 0.05). In different N stages. The serum levels of Ang-2 and Tie-2 in patients with metastatic nasopharyngeal carcinoma were significantly higher than those in patients without metastasis (P0.01). The ratio of serum Ang-1/Ang-2 in patients with stage 鈪，

本文編號：1446138