星狀神經(jīng)節(jié)阻滯結(jié)合三叉神經(jīng)節(jié)脈沖射頻治療面部PHN的效果研究
發(fā)布時(shí)間：2019-06-03 21:34
【摘要】：目的:分析星狀神經(jīng)節(jié)阻滯聯(lián)合三叉神經(jīng)節(jié)脈沖射頻對(duì)顏面帶狀皰疹后遺神經(jīng)痛(postherpetic neuralgia PHN)的治療效果,并調(diào)查血清IL-2和IL-6在治療前后的水平變化。方法:選取顏面部PHN病患者60例,按治療方案分為星狀神經(jīng)節(jié)阻滯治療組(A組),接受三叉神經(jīng)節(jié)脈沖射頻治療(B組),聯(lián)合兩種治療組(C組),每組20例。分別記錄治療前與治療后六個(gè)月的的視覺模擬評(píng)分(visual analogue scale VAS)和生存質(zhì)量評(píng)分(quality of life QOL),疼痛發(fā)作時(shí)頭面部疼的程度,使用鎮(zhèn)痛藥的劑量,發(fā)生及固定時(shí)間內(nèi)出現(xiàn)的次數(shù)以及出現(xiàn)時(shí)長(zhǎng)、有無并發(fā)癥。采用放射免疫測(cè)定法治療前后患者血清中IL-2和IL-6的水平。結(jié)果:治療前、后6個(gè)月VAS評(píng)分A組(7.56土0.92 vs 3.31 ±0.40)、B組(7.51±0.80vs 2.81±0.45)和C組(7.63士0.68vs 2.06±0.55),均顯著下降并具有統(tǒng)計(jì)學(xué)差異(P0.001)。治療前和治療后6個(gè)月的QOL評(píng)分進(jìn)行比較結(jié)果A組(34.64±2.83 vs 72.62±2.07)、B 組(33.51±2.47 vs 72.84±2.40)和 C 組(32.12±3.00 vs 79.82±3.79),均顯著上升并具有統(tǒng)計(jì)學(xué)差異(P0.001)。術(shù)后6個(gè)月疼痛緩解程度百分比C組(70%)明顯高于A組(25%)及B組(30%)(P0.05),疼痛發(fā)作時(shí)持續(xù)時(shí)間 A 組(10.54±0.31 vs 4.38±0.33)、B 組(10.16±0.49 vs 3.74±0.53)、C 組(10.41 ±0.43 vs 3.41±0.67)較術(shù)前均明顯減少(P0.05),且具有統(tǒng)計(jì)學(xué)意義。術(shù)后各組血清白介素2水平較術(shù)前(A組:2.49±0.81 vs 2.56±0.72;B組:2.52±0.79vs 2.55士0.82;C組:2.54±0.78vs 2.61±0.78ng/ml)均有所上升,但上升幅度不明顯(P0.05),白介素6水平相較術(shù)前(A組:244.65±48.15vs 243.51±48.12;B組:243.62±47.95 vs 242.61±47.92;C組:242.38±46.95 vs 241.01±46.85 pg/ml)均有所下降,但下降幅度不明顯(P0.05)。結(jié)論:三叉神經(jīng)節(jié)脈沖射頻以及星狀神經(jīng)節(jié)相結(jié)合的療法相對(duì)于單獨(dú)行星狀神經(jīng)節(jié)阻滯以及三叉神經(jīng)節(jié)脈沖射頻這兩種方法對(duì)于治療面部PHN的效果有著明顯的提升。且上述治療方法并不能明顯改善面部PHN患者血清白介素2以及白介素6的水平。
[Abstract]:Objective: To analyze the therapeutic effect of stellate ganglion block combined with trigeminal ganglion pulse radio frequency on postherpetic neuralgia (PHN), and to investigate the level changes of serum IL-2 and IL-6 before and after treatment. Methods:60 patients with PHN were randomly divided into the group of stellate ganglion block (group A), and received the pulse-frequency therapy of the trigeminal ganglion (group B), and the combination of the two treatment groups (group C) was 20 cases in each group. The visual analogue scale (VAS) and the quality of life QOL (quality of life QOL) before and after the treatment were recorded separately, the degree of the head's face pain during the pain attack, the number of times in which the analgesic was used, the number of times of occurrence and fixation time, and the duration of the occurrence, and the presence or absence of complications. The levels of IL-2 and IL-6 in serum of patients before and after treatment were measured by radioimmunoassay. Results: The VAS scores in group A (7.56, 0.92 vs. 3.31, 0.40), group B (7.51, 0.80 vs 2.81, 0.45) and C (7.63 + 0.68 vs 2.06-0.55) were significantly decreased before and after treatment (P 0.001). The QOL scores before and after treatment were compared in group A (34.64, 2.83 vs 72.62, 2.07), group B (33.51, 2.47 vs 72.84, 2.40) and group C (32.12, 3.00 vs. 79.82, 3.79), both significantly and statistically different (P0.001). The percentage of pain relief in group C (70%) was significantly higher than that in group A (25%) and group B (30%) (P0.05). The duration of pain in group A (10.54, 0.31 vs. 4.38, 0.33), group B (10.16, 0.49 vs. 3.74, 0.53) was significantly higher in group C than in group A (25%) and group B (30%) (P0.05). The group C (10.41-0.43 vs. 3.41-0.67) was significantly reduced before operation (P0.05), and was of statistical significance. The level of IL-2 in the group was 2.49 (0.81 vs 2.56, 0.72; group B: 2.52, 0.79 vs 2.55 + 0.82; Group C: 2.54, 0.78 vs 2.61, 0.78 ng/ ml), but the rise was not significant (P0.05), and the level of interleukin6 was not significant (group A: 244.65, 48.15 vs. 243.51, 48.12; Group B: 243.62 (47.95 vs 242.61, 47.92; Group C: 242.38, 46.95 vs 241.01, 46.85 pg/ ml) decreased, but the decrease was not significant (P0.05). Conclusion: The combination of the trigeminal ganglion pulse radio frequency and the stellate ganglion has a significant improvement in the treatment of the face PHN with respect to the individual planetary ganglion block and the trigeminal ganglion pulse radio frequency. And the treatment method can not obviously improve the level of the serum interleukin 2 and the interleukin 6 in the face PHN patients.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R614
，
本文編號(hào)：2492234
[Abstract]:Objective: To analyze the therapeutic effect of stellate ganglion block combined with trigeminal ganglion pulse radio frequency on postherpetic neuralgia (PHN), and to investigate the level changes of serum IL-2 and IL-6 before and after treatment. Methods:60 patients with PHN were randomly divided into the group of stellate ganglion block (group A), and received the pulse-frequency therapy of the trigeminal ganglion (group B), and the combination of the two treatment groups (group C) was 20 cases in each group. The visual analogue scale (VAS) and the quality of life QOL (quality of life QOL) before and after the treatment were recorded separately, the degree of the head's face pain during the pain attack, the number of times in which the analgesic was used, the number of times of occurrence and fixation time, and the duration of the occurrence, and the presence or absence of complications. The levels of IL-2 and IL-6 in serum of patients before and after treatment were measured by radioimmunoassay. Results: The VAS scores in group A (7.56, 0.92 vs. 3.31, 0.40), group B (7.51, 0.80 vs 2.81, 0.45) and C (7.63 + 0.68 vs 2.06-0.55) were significantly decreased before and after treatment (P 0.001). The QOL scores before and after treatment were compared in group A (34.64, 2.83 vs 72.62, 2.07), group B (33.51, 2.47 vs 72.84, 2.40) and group C (32.12, 3.00 vs. 79.82, 3.79), both significantly and statistically different (P0.001). The percentage of pain relief in group C (70%) was significantly higher than that in group A (25%) and group B (30%) (P0.05). The duration of pain in group A (10.54, 0.31 vs. 4.38, 0.33), group B (10.16, 0.49 vs. 3.74, 0.53) was significantly higher in group C than in group A (25%) and group B (30%) (P0.05). The group C (10.41-0.43 vs. 3.41-0.67) was significantly reduced before operation (P0.05), and was of statistical significance. The level of IL-2 in the group was 2.49 (0.81 vs 2.56, 0.72; group B: 2.52, 0.79 vs 2.55 + 0.82; Group C: 2.54, 0.78 vs 2.61, 0.78 ng/ ml), but the rise was not significant (P0.05), and the level of interleukin6 was not significant (group A: 244.65, 48.15 vs. 243.51, 48.12; Group B: 243.62 (47.95 vs 242.61, 47.92; Group C: 242.38, 46.95 vs 241.01, 46.85 pg/ ml) decreased, but the decrease was not significant (P0.05). Conclusion: The combination of the trigeminal ganglion pulse radio frequency and the stellate ganglion has a significant improvement in the treatment of the face PHN with respect to the individual planetary ganglion block and the trigeminal ganglion pulse radio frequency. And the treatment method can not obviously improve the level of the serum interleukin 2 and the interleukin 6 in the face PHN patients.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R614
，
本文編號(hào)：2492234
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