發(fā)布時(shí)間：2019-01-26 07:52

【摘要】：目的分析定量超聲測(cè)定跟骨骨密度(BMD)對(duì)骨質(zhì)疏松性骨折的判斷價(jià)值,并探討B(tài)MD與患者血清骨代謝、骨轉(zhuǎn)化指標(biāo)的相關(guān)性。方法將2013年8月至2015年8月期間在北京大學(xué)深圳醫(yī)院接受檢查治療的骨質(zhì)疏松性骨折患者72例作為觀察組,另取同期在本院接受健康體檢、不伴骨質(zhì)疏松的老年人群68例作為對(duì)照組,比較兩組患者的定量超聲下BMD值、血清骨代謝、骨轉(zhuǎn)化指標(biāo)值的差異,并進(jìn)一步分析BMD與骨質(zhì)疏松性骨折患者病情的關(guān)系。結(jié)果觀察組患者的BMD為(0.23±0.04)g/cm2、25羥維生素D(25OHD)為(39.27±4.51)nmol/L、骨鈣素N端中分子片段(N-MID)為(56.18±7.29)ng/m L、人降鈣素(HCT)為(2.41±0.32)ng/L,均相應(yīng)低于對(duì)照組的(0.35±0.05)g/cm2、(57.63±6.92)nmol/L、(82.55±9.04)ng/m L、(3.17±0.42)ng/L,而堿性磷酸酶(ALP)為(56.27±6.19)IU/L、Ⅰ型前膠原N末端前肽(PINP)為(42.18±5.29)μg/L、抗酒石酸酸性磷酸酶(TRAP)為(4.63±0.53)U/L、β-膠原降解產(chǎn)物(β-CTX)為(64.39±7.11)ng/m L,均高于對(duì)照組的(27.45±3.38)IU/L、(24.76±3.08)μg/L、(3.11±0.37)U/L、(45.28±5.29)ng/m L,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。經(jīng)一元線性回歸分析發(fā)現(xiàn),骨質(zhì)疏松性骨折患者的BMD值與血清25OHD、N-MID、HCT值呈正相關(guān)(r=0.627、0.701、0.598),與ALP、PINP、TRAP、β-CTX呈負(fù)相關(guān)(r=-0.582、-0.672、-0.693,P0.05)。結(jié)論定量超聲測(cè)定跟骨骨密度可以客觀判斷骨質(zhì)疏松性骨折的嚴(yán)重度,其與患者的血清學(xué)指標(biāo)存在良好的相關(guān)關(guān)系,可以作為臨床病情監(jiān)測(cè)及預(yù)后判斷的可靠手段。
[Abstract]:Objective to analyze the value of quantitative ultrasound measurement of calcaneal bone mineral density (BMD) in the diagnosis of osteoporotic fracture and to explore the correlation between BMD and serum bone metabolism and bone transformation index. Methods from August 2013 to August 2015, 72 patients with osteoporotic fracture were examined in Shenzhen Hospital of Peking University as the observation group. Sixty-eight elderly people without osteoporosis were used as control group to compare the difference of BMD value, serum bone metabolism and bone transformation index between the two groups under quantitative ultrasound, and to further analyze the relationship between BMD and the condition of patients with osteoporosis fracture. Results the BMD of the observation group was (0.23 鹵0.04) g / cm ~ (2) ~ (25) hydroxyvitamin D (25OHD) = (39.27 鹵4.51) nmol/L, N-MID = (56.18 鹵7.29) ng/m / L, respectively. Human calcitonin (HCT) (2.41 鹵0.32) ng/L, was significantly lower than that of control group (0.35 鹵0. 05) g / cm ~ (2), (57.63 鹵6.92) nmol/L, (82.55 鹵9.04) ng/m L, (3.17 鹵0.42) ng/L,. The (ALP) of alkaline phosphatase was (56.27 鹵6.19) IU/L, 鈪，

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