【摘要】：目的探討右美托咪定對甲狀腺手術患者嗆咳反應的影響。方法擇期全麻下甲狀腺腫瘤手術患者118例,男43例,女75例,年齡18~65歲,BMI 18~30kg/m2,ASAⅠ或Ⅱ級,采用隨機數(shù)字表法分為兩組,每組59例。D組在手術開始時持續(xù)靜脈泵注右美托咪定0.4μg·kg~(-1)·h~(-1)至手術結束,C組在手術開始時持續(xù)靜脈泵注等容量生理鹽水至手術結束。觀察患者全麻恢復期間嗆咳發(fā)生情況,記錄患者術后24、48h引流量,以及心動過速、低血壓、高血壓、心動過緩等不良反應的發(fā)生情況。結果 D組全麻恢復期間嗆咳發(fā)生率明顯低于C組(10.1%vs 30.5%,P0.05),D組術后第1個24h[(62.3±26.8)ml vs(78.6±30.1)ml,P0.05]、第2個24h[(28.0±12.5)ml vs(37.5±18.6)ml,P0.05]引流量明顯少于C組;D組圍術期心動過速發(fā)生率明顯低于C組(3.4%vs 23.7%,P0.05)。結論術中持續(xù)輸注右美托咪定0.4μg·kg-1·h-1能夠有效減輕甲狀腺手術患者全麻恢復期間的嗆咳反應,降低患者術后出血的風險。
[Abstract]:Objective to investigate the effect of dexmetomidine on cough response in patients undergoing thyroid surgery. Methods one hundred and eighteen patients (43 males and 75 females) with thyroid neoplasms undergoing elective general anesthesia were divided into two groups by random digital table. The patients were aged 1865 years, with BMI 1830kg / m2 ASA 鈪，

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