【摘要】：老年人肌少性肥胖(sarcopenic obesity,SO)是一種伴隨著肥胖的骨骼肌質量和功能下降的老年性疾病,多發(fā)于老年人群而嚴重影響其生活質量。大量研究結果表明隨著年齡的增長,即使體質量不變,老年人身體組成也會逐漸改變,肌肉質量功能下降,脂肪比例上升且主要堆積在肌肉組織、內臟器官,整體表現(xiàn)為肌肉脂肪量上升、炎癥因子增多、生長激素水平下降、營養(yǎng)攝入不足、活動量降低、神經(jīng)元功能下降以及胰島素抵抗等,這些現(xiàn)象都與SO相關。從分子水平闡述其相關機制,研究者發(fā)現(xiàn)骨骼肌蛋白質合成與降解、骨骼肌糖脂代謝以及相關細胞因子均參與SO代謝通路的調控。運動干預、熱量限制及蛋白質、VD、β-羥基-β-甲基丁酸鹽、肌酸和乳清蛋白的攝入均可在一定程度上起到防治SO的效果。由于國內外對于SO的判斷標準、發(fā)病機制以及防治手段仍不統(tǒng)一,給SO研究帶來了較大難度。本文對國內外最新研究報道進行整理總結,從SO的定義、引起因素、涉及的細胞信號調控通路以及防治策略(運動或營養(yǎng)食品干預)等方面進行了綜述,為SO治療提供新思路。
[Abstract]:Sarcopenic obesityso is a kind of senile disease which is accompanied by the decline of skeletal muscle quality and function in the elderly. It mainly affects the quality of life in the elderly. A large number of studies have shown that with age, even if the body mass remains constant, the body composition of the elderly will gradually change, the muscle mass function will decline, the fat ratio will increase and mainly accumulate in muscle tissue, visceral organs, The results showed that the increase of muscle fat, the increase of inflammatory factors, the decrease of growth hormone level, the deficiency of nutrition intake, the decrease of activity, the decrease of neuron function and insulin resistance were all related to so. At the molecular level, it was found that protein synthesis and degradation of skeletal muscle, glycolipid metabolism of skeletal muscle and related cytokines were involved in the regulation of so metabolism pathway. Exercise intervention, caloric restriction and intake of protein VD, 尾 -hydroxy- 尾 -methylbutyrate, creatine and whey protein all played a role in preventing and treating so to a certain extent. It is difficult to study so because the criteria, pathogenesis, prevention and cure of so are not uniform at home and abroad. In this paper, the latest research reports at home and abroad are summarized, including the definition of so, the cause factors, the cellular signal regulation pathway involved, and the prevention and treatment strategies (exercise or nutritional food intervention), which provide a new way of thinking for so therapy.
【作者單位】： 武漢體育學院研究生院;武漢體育學院健康科學學院天久運動營養(yǎng)食品研發(fā)中心;
【基金】：國家自然科學基金面上項目(31571228) 國家體育總局科教司科學研究項目(2014B093) 湖北省高等學校優(yōu)秀中青年科技創(chuàng)新團隊項目(T201624) 湖北省體育教育與健康促進學科群項目
【分類號】：R685
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本文編號：2184128