嚴重創(chuàng)傷失血多器官功能不全綜合征患者胰島β細胞功能與感染炎癥和主要臟器功能的相關性
發(fā)布時間：2018-07-28 14:50
【摘要】：目的分析嚴重創(chuàng)傷失血多器官功能不全綜合征(MODS)患者胰島β細胞功能與感染炎癥及主要臟器功能之間的關系。方法選取2013年1月至2016年1月解放軍第九四醫(yī)院住院部收治的各種創(chuàng)傷MODS患者187例,按結局分為MODS生存組(MODS-S組,104例)和MODS病死組(MODS-D組,83例);另選取同期體檢健康者100例作為對照組。測定3組空腹時血糖(GLU0)和胰島素(INS0)水平,糖負荷30 min后血糖(GLU30)和胰島素(INS30)水平,以及血可溶性髓樣細胞觸發(fā)受體-1(sTREM-1)、腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)、丙氨酸氨基轉移酶(ALT)、肌酐(Cre)和肌酸激酶同工酶(CK-MB)等指標水平;以穩(wěn)態(tài)模式評估法胰島素分泌指數(shù)(HOMA-β)和糖負荷30min后胰島素增量和血糖增量比值(ΔINS30/ΔGLU30)評估胰島β細胞功能,并分析與其他各項指標的關系。結果 MODS-D組HOMA-β和ΔINS30/ΔGLU30均明顯低于MODS-S組,sTREM-1、TNF-α、IL-6、ALT、Cre、CK-MB水平均明顯高于MODS-S組,差異均有統(tǒng)計學意義(P0.01);嚴重創(chuàng)傷失血MODS患者HOMA-β和ΔINS30/ΔGLU30分別與血sTREM-1、TNF-α、IL-6、GLU0、ALT、Cre及CK-MB呈明顯負相關(r=-0.356 4、-0.532 1、-0.345 8、-0.772 1、-0.762 5、-0.684 8、-0.606 4,r=-0.428 5、-0.567 8、-0.487 0、-0.743 6、-0.781 7、-0.717 6、-0.640 1,P0.01)。結論嚴重創(chuàng)傷失血MODS患者存在胰島β細胞功能不全,可以作為患者預后的診斷指標。
[Abstract]:Objective to analyze the relationship between islet 尾 cell function and infection inflammation and main organ function in (MODS) patients with severe traumatic haemorrhage multiple organ dysfunction syndrome. Methods from January 2013 to January 2016, 187 MODS patients with various trauma were selected. According to the outcome, the patients were divided into MODS survival group (MODS-S group, 104 cases) and MODS group (MODS-D group, 83 cases), and 100 healthy persons in the same period as control group. Fasting blood glucose (GLU0) and insulin (INS0) were measured in three groups, and blood glucose (GLU30) and insulin (INS30) were measured after 30 min of glucose load. Serum soluble myeloid cell trigger receptor 1 (sTREM-1), tumor necrosis factor- 偽 (TNF- 偽), interleukin-6 (IL-6), alanine aminotransferase (ALT),) creatinine (Cre) and creatine kinase isoenzyme (CK-MB) were also measured. Insulin secretion index (HOMA- 尾) and insulin increment and glucose increment ratio (螖 INS30/ 螖 GLU30) after glucose load 30min were evaluated by homeostasis model method, and the relationship between insulin secretion index (HOMA- 尾) and other indexes was analyzed. 緇撴灉 MODS-D緇凥OMA-尾鍜屛擨NS30/螖GLU30鍧囨槑鏄句綆浜嶮ODS-S緇，
本文編號：2150590
[Abstract]:Objective to analyze the relationship between islet 尾 cell function and infection inflammation and main organ function in (MODS) patients with severe traumatic haemorrhage multiple organ dysfunction syndrome. Methods from January 2013 to January 2016, 187 MODS patients with various trauma were selected. According to the outcome, the patients were divided into MODS survival group (MODS-S group, 104 cases) and MODS group (MODS-D group, 83 cases), and 100 healthy persons in the same period as control group. Fasting blood glucose (GLU0) and insulin (INS0) were measured in three groups, and blood glucose (GLU30) and insulin (INS30) were measured after 30 min of glucose load. Serum soluble myeloid cell trigger receptor 1 (sTREM-1), tumor necrosis factor- 偽 (TNF- 偽), interleukin-6 (IL-6), alanine aminotransferase (ALT),) creatinine (Cre) and creatine kinase isoenzyme (CK-MB) were also measured. Insulin secretion index (HOMA- 尾) and insulin increment and glucose increment ratio (螖 INS30/ 螖 GLU30) after glucose load 30min were evaluated by homeostasis model method, and the relationship between insulin secretion index (HOMA- 尾) and other indexes was analyzed. 緇撴灉 MODS-D緇凥OMA-尾鍜屛擨NS30/螖GLU30鍧囨槑鏄句綆浜嶮ODS-S緇，
本文編號：2150590
本文鏈接：http://www.sikaile.net/yixuelunwen/waikelunwen/2150590.html
最近更新
教材專著
