【摘要】：目的對(duì)硫酸乙酰肝素(heparan sulfate,HS)在骨形成和骨重建方面的作用進(jìn)行討論,綜述其成骨機(jī)制的最新研究進(jìn)展。方法查閱國(guó)內(nèi)外有關(guān)HS體外作用于成骨細(xì)胞系、HS和HS復(fù)合支架材料作用于骨缺損動(dòng)物模型以及HS蛋白聚糖影響骨骼發(fā)育的研究文獻(xiàn),并進(jìn)行綜合分析。結(jié)果 HS長(zhǎng)鏈通過(guò)非共價(jià)結(jié)合方式和參與骨折愈合的生長(zhǎng)因子結(jié)合,尤其是肝素結(jié)合性生長(zhǎng)因子(如FGFs、BMP、TGF-β)等,保護(hù)這些生長(zhǎng)因子免受蛋白酶降解,并可直接參與生長(zhǎng)因子信號(hào)轉(zhuǎn)導(dǎo)和骨細(xì)胞功能調(diào)節(jié)。HS調(diào)控成骨作用機(jī)制主要包括:刺激干細(xì)胞向成骨細(xì)胞分化、提高成骨細(xì)胞分化能力、促進(jìn)骨基質(zhì)形成、維持骨基質(zhì)穩(wěn)定和加速骨基質(zhì)礦化。結(jié)論 HS的成骨作用顯著,隨著對(duì)其安全性的不斷探索完善,HS可能成為臨床治療骨缺損延遲愈合和不愈合的有效手段,并有望為骨組織工程技術(shù)提供更多選擇。
[Abstract]:Objective to discuss the role of heparan sulfate heparin (heparan sulfate) in bone formation and bone reconstruction, and to review the latest research progress of its osteogenic mechanism. Methods the domestic and foreign literatures about the effects of HS on osteoblast cell line HS and HS composite scaffold on bone defect animal model and the effect of HS proteoglycan on bone development were reviewed and analyzed. Results HS long chain could protect these growth factors from protease degradation by non-covalent binding with growth factors involved in fracture healing, especially heparin binding growth factors (such as FGFsPMP TGF- 尾). The mechanism of regulating osteogenesis mainly includes stimulating the differentiation of stem cells into osteoblasts, enhancing the differentiation ability of osteoblasts, and promoting the formation of bone matrix, which can directly participate in the signal transduction of growth factor and the regulation of osteocyte function. Maintain bone matrix stability and accelerate bone matrix mineralization. Conclusion HS plays a significant role in osteogenesis, and with the continuous exploration and improvement of its safety, HS may become an effective method for the treatment of delayed healing and nonunion of bone defects, and it is expected to provide more options for bone tissue engineering techniques.
【作者單位】： 南京醫(yī)科大學(xué)附屬無(wú)錫市人民醫(yī)院骨科;江南大學(xué)藥學(xué)院藥用生物高分子研究室;
【基金】：國(guó)家自然科學(xué)基金面上項(xiàng)目(21574059)~~
【分類號(hào)】：R318.08;R68

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1 宋淑軍;王宗燁;;硫酸乙酰肝素在骨折愈合中的作用[J];生命的化學(xué);2008年04期

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本文編號(hào)：2119903