發(fā)布時(shí)間：2018-04-17 17:05

  本文選題：創(chuàng)傷性顱腦損傷 + 七氟烷　； 參考：《中國(guó)免疫學(xué)雜志》2017年10期

【摘要】：目的:探討七氟烷麻醉對(duì)急性創(chuàng)傷性顱腦損傷患者圍手術(shù)期炎癥介質(zhì)表達(dá)、神經(jīng)功能損害及患者預(yù)后的影響。方法:收集2015年7月至2016年12月急診開顱手術(shù)的創(chuàng)傷性顱腦損傷患者80例,隨機(jī)分為試驗(yàn)組(七氟烷處理組)和對(duì)照組,各40例。圍手術(shù)期抽取外周血,利用酶聯(lián)免疫吸附測(cè)定法檢測(cè)血清中TNF-α、IL-6、CRP蛋白和NSE濃度,比較兩組患者GCS評(píng)分、APACHEⅡ評(píng)分和預(yù)后。結(jié)果:與對(duì)照組比較,試驗(yàn)組在術(shù)中1 h、術(shù)畢和術(shù)后第1天血清炎癥介質(zhì)(CRP、TNF-α、IL-6)表達(dá)明顯降低(P0.05或0.01),神經(jīng)元特異性烯醇化酶NSE蛋白在術(shù)畢及術(shù)后第1天表達(dá)降低(P0.05或0.01);七氟烷處理有效改善患者病情,在第14天GCS評(píng)分[(10.82±1.40)比(8.29±1.02),P=0.03],APACHEⅡ評(píng)分[(14.42±1.97)比(18.03±2.15),P=0.02]。結(jié)論:七氟烷處理可通過(guò)抑制創(chuàng)傷性顱腦損傷患者圍手術(shù)期傷后炎癥反應(yīng),減少神經(jīng)元細(xì)胞損害,起到神經(jīng)保護(hù)作用和改善患者預(yù)后。
[Abstract]:Aim: to investigate the effect of sevoflurane anesthesia on the expression of inflammatory mediators, neurological impairment and prognosis in patients with acute traumatic brain injury.Methods: 80 patients with traumatic craniocerebral injury underwent emergency craniotomy from July 2015 to December 2016 were randomly divided into experimental group (sevoflurane treated group) and control group (40 cases each).Peripheral blood was drawn from perioperative period. Serum TNF- 偽 IL-6 CRP protein and NSE concentration were detected by enzyme linked immunosorbent assay (Elisa). The GCS score and Apache 鈪，

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