本文選題：術(shù)后認(rèn)知功能障礙　切入點(diǎn)：手術(shù)　出處：《中南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年11期 　論文類型：期刊論文

【摘要】：術(shù)后認(rèn)知功能障礙(postoperative cognitive dysfunction,POCD)是一種輕度的認(rèn)知功能紊亂,是指術(shù)前無認(rèn)知障礙的患者在麻醉手術(shù)后出現(xiàn)精神活動(dòng)、人格、社交活動(dòng)及認(rèn)知能力的改變。記憶減退是認(rèn)知功能障礙患者的核心癥狀及表現(xiàn),年齡是術(shù)后長期認(rèn)知功能損害的主要危險(xiǎn)因素。POCD的發(fā)生將延長患者的住院時(shí)間,降低患者的生存質(zhì)量,增加術(shù)后死亡率,給個(gè)人和社會(huì)造成嚴(yán)重負(fù)擔(dān)。如何有效地預(yù)防、干預(yù)POCD的發(fā)生發(fā)展,減少不良后果,是手術(shù)患者(尤其是老年患者)圍手術(shù)期亟需解決的問題。雖然POCD的病理生理機(jī)制仍然不明,但目前傾向于認(rèn)為炎癥在POCD中扮演重要作用。無菌手術(shù)誘導(dǎo)外周炎癥反應(yīng),通過相關(guān)途徑傳入中樞,因個(gè)體差異,導(dǎo)致了不同嚴(yán)重程度的中樞炎癥反應(yīng),進(jìn)而引起POCD。因此,針對(duì)POCD的防治方法也應(yīng)著重圍繞減輕炎癥反應(yīng)展開。
[Abstract]:Postoperative cognitive dysfunctional POCDD is a mild cognitive disorder, which refers to the mental activity and personality of patients without cognitive impairment before anesthesia. Memory impairment is the core symptom and manifestation of cognitive dysfunction. Age is the main risk factor of long-term cognitive impairment. POCD will prolong the hospitalization time of the patients. How to effectively prevent and intervene in the occurrence and development of POCD, and reduce the adverse consequences, reduce the quality of life of patients, increase the postoperative mortality, and cause a serious burden to individuals and society. Although the pathophysiological mechanism of POCD is still unknown, it tends to think that inflammation plays an important role in POCD. Because of the individual difference, the central inflammatory reaction of different severity is caused by the relevant pathway. Therefore, the prevention and treatment of POCD should focus on alleviating the inflammatory reaction.
【作者單位】： 中南大學(xué)湘雅三醫(yī)院麻醉科;
【基金】：國家自然科學(xué)基金(81371216)~~
【分類號(hào)】：R614
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本文編號(hào)：1640887