本文關鍵詞： 乳腺癌 鹽酸帕洛諾司瓊膠囊 鹽酸托烷司瓊 嘔吐　出處：《臨床軍醫(yī)雜志》2016年11期 　論文類型：期刊論文

【摘要】：目的探討鹽酸帕洛諾司瓊膠囊與鹽酸托烷司瓊在預防及治療乳腺癌患者術(shù)后行環(huán)磷酰胺聯(lián)合表柔比星方案(AC方案)輔助化療引起的惡心、嘔吐等消化道反應的療效。方法選擇2012年5月至2015年4月在沈陽軍區(qū)總醫(yī)院腫瘤科住院的確診為三陰性乳腺癌術(shù)后患者36例為研究對象,統(tǒng)一采用AC方案化療。將36例患者隨機分為A、B兩組,每組各18例。A組患者化療前30 min使用鹽酸帕洛諾司瓊膠囊+阿瑞匹坦+地塞米松;B組患者使用鹽酸托烷司瓊+阿瑞匹坦+地塞米松,以防治惡心、嘔吐。比較兩組患者化療后急性嘔吐及延遲性嘔吐的緩解率,并觀察兩組患者用藥后頭痛、便秘、眩暈等不良反應的發(fā)生率。結(jié)果 A組總有效率為94.4%,B組總有效率為77.8%,兩組總有效率比較,差異無統(tǒng)計學意義(P0.05)。但在急性嘔吐期,A組的完全緩解率(83.3%)明顯高于B組(50.0%),兩組比較,差異有統(tǒng)計學意義(P0.05);同時,延遲期嘔吐的緩解率,A組的完全緩解率(44.4%)同樣高于B組(11.1%),且兩組比較,差異也有統(tǒng)計學意義(P0.05)。在不良反應的比較中,A組便秘及胃腸道紊亂發(fā)生率低于B組,兩組比較,差異有統(tǒng)計學意義(P0.05)。結(jié)論鹽酸帕洛諾司瓊膠囊在化療相關性嘔吐的治療中,療效明顯優(yōu)于鹽酸托烷司瓊;其不良反應的發(fā)生率也明顯低于鹽酸托烷司瓊。
[Abstract]:Objective to investigate the effects of paronosetron hydrochloride capsule and tropisetron hydrochloride on postoperative nausea caused by cyclophosphamide combined with epirubicin (AC) regimen in the prevention and treatment of breast cancer. Methods from May 2012 to April 2015, 36 patients with triple-negative breast cancer who were hospitalized in the Department of Oncology, Shenyang military region General Hospital were selected as the study objects. 36 patients were randomly divided into two groups: group A and group B. 18 patients in group A were treated with parapisetron hydrochloride and dexamethasone hydrochloride for 30 min before chemotherapy. Group B patients received tropisetron hydrochloride and albitam dexamethasone in order to prevent and treat nausea. To compare the remission rate of acute vomiting and delayed vomiting after chemotherapy in two groups, and to observe the headache and constipation after treatment. Results the total effective rate of group A was 94.4% and the total effective rate of group B was 77.8. There was no significant difference in the total effective rate between the two groups, but the complete remission rate of group A during acute vomiting was significantly higher than that of group B (83.3%). At the same time, the complete remission rate of group A was also higher than that of group B (P 0.05), and the complete remission rate of group A was higher than that of group B (P < 0.01). The incidence of constipation and gastrointestinal disorders in group A was lower than that in group B, and the difference was statistically significant between the two groups. Conclusion Palonosetron hydrochloride capsule can be used in the treatment of chemotherapy-associated vomiting. The efficacy of tropisetron hydrochloride was better than that of tropisetron hydrochloride, and the incidence of adverse reactions was significantly lower than that of tropisetron hydrochloride.
【作者單位】： 中國醫(yī)科大學腫瘤醫(yī)院遼寧省腫瘤醫(yī)院內(nèi)五科;
【分類號】：R737.9

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