本文關(guān)鍵詞：自擬接骨促愈方聯(lián)合阿法骨化醇對(duì)新鮮四肢骨折患者術(shù)后愈合進(jìn)程及BMP、IGF、VEGF的影響　出處：《現(xiàn)代中西醫(yī)結(jié)合雜志》2016年34期 　論文類型：期刊論文

  更多相關(guān)文章： 中藥 四肢骨折 手術(shù) 愈合

【摘要】：目的觀察自擬接骨促愈方聯(lián)合阿法骨化醇對(duì)新鮮四肢骨折患者術(shù)后愈合進(jìn)程及血清骨形態(tài)發(fā)生蛋白2(BMP-2)、胰島素樣生長(zhǎng)因子(IGF)及血管內(nèi)皮生長(zhǎng)因子(VEGF)的影響。方法將140例子新鮮四肢骨折患者隨機(jī)分為2組,對(duì)照組70例采用阿法骨化醇治療,觀察組70例在此基礎(chǔ)上加用自擬接骨促愈方輔助治療。統(tǒng)計(jì)2組臨床癥狀消失時(shí)間、骨折愈合時(shí)間,觀察2組治療前后骨痂生長(zhǎng)評(píng)分及血清BMP-2、IGF-Ⅰ、IGF-Ⅱ及VEGF水平變化情況。結(jié)果觀察組疼痛、腫脹及淤斑消失時(shí)間和骨折愈合時(shí)間均顯著短于對(duì)照組(P均0.05);2組治療后骨痂量、骨痂密度、骨痂邊緣及斷端邊緣骨痂生長(zhǎng)評(píng)分均顯著高于治療前(P均0.05),且觀察組各項(xiàng)評(píng)分均顯著高于對(duì)照組(P均0.05);2組治療后血清BMP-2、IGF-Ⅰ、IGF-Ⅱ及VEGF水平均顯著高于治療前(P均0.05),且觀察組治療后各項(xiàng)指標(biāo)水平均顯著高于對(duì)照組(P均0.05)。結(jié)論自擬接骨促愈方聯(lián)合阿法骨化醇治療新鮮四肢骨折可有效促進(jìn)臨床癥狀消失,加快術(shù)后愈合進(jìn)程,并有助于上調(diào)BMP-2、IGF-I、IGF-II及VEGF水平。
[Abstract]:Objective to observe the healing process and serum bone morphogenetic protein (BMP-2) in patients with fresh limb fracture treated by self-made bone healing prescription combined with Alfacalciol. Methods 140 patients with fresh limb fractures were randomly divided into two groups. The control group (70 cases) was treated with Alfacalciol, and the observation group (70 cases) was treated with self-made bone healing prescription. The clinical symptoms disappeared and fracture healing time was counted. The changes of callus growth score and serum BMP-2IGF- 鈪，

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