發(fā)布時(shí)間：2019-08-05 10:32

【摘要】：目的評(píng)價(jià)腦動(dòng)脈低溫時(shí)Willis環(huán)結(jié)構(gòu)對(duì)腦組織溫度的影響。方法基于患者腦血管CT圖像構(gòu)建腦Willis環(huán)體外模型,并通過(guò)灌流實(shí)驗(yàn)經(jīng)右側(cè)頸內(nèi)動(dòng)脈以30 mL/min的速度注入20℃冷水至中腦動(dòng)脈,15 min后停止注入,通過(guò)27根和1根空間排布的熱電偶觀察中腦動(dòng)脈周圍區(qū)域以及流體的降溫及復(fù)溫特性,并通過(guò)注入染色溶液對(duì)冷水影響區(qū)域進(jìn)行可視化。結(jié)果由右側(cè)頸內(nèi)動(dòng)脈進(jìn)行低溫誘導(dǎo)時(shí),冷水溶液主要影響右側(cè)區(qū)域,也有少部分通過(guò)前腦交通動(dòng)脈進(jìn)入前腦動(dòng)脈;離冷流體所經(jīng)過(guò)的血管越近的區(qū)域在較快獲得低溫的同時(shí),也會(huì)有較快的復(fù)溫速率;由于受多個(gè)分叉血管的影響,垂直于中腦動(dòng)脈流動(dòng)方向?qū)ΨQ區(qū)域的溫度分布呈非對(duì)稱性。結(jié)論本文首次運(yùn)用物理模型對(duì)腦動(dòng)脈低溫進(jìn)行驗(yàn)證,為研究血管結(jié)構(gòu)對(duì)腦動(dòng)脈低溫的影響以及設(shè)計(jì)個(gè)性化低溫治療方案提供依據(jù)。
[Abstract]:Objective to evaluate the effect of Willis ring structure on brain tissue temperature during cerebral artery hypothermia. Methods the in vitro model of cerebral Willis ring was established based on the cerebral vascular CT images of the patients. The right internal carotid artery was injected with cold water at 20 鈩，

本文編號(hào)：2523076