發(fā)布時(shí)間：2019-02-13 21:00

【摘要】：目的該實(shí)驗(yàn)通過測試不同劑量木糖醇對慶大霉素骨水泥不同時(shí)間點(diǎn)抗生素釋出量及試件生物力學(xué)強(qiáng)度,初步探討木糖醇添加劑對慶大霉素骨水泥的體外釋放及生物力學(xué)的影響,為臨床應(yīng)用抗生素骨水泥提供實(shí)驗(yàn)依據(jù)。方法將不同配比的抗生素骨水泥40 g添加11及22 g木糖醇并與對照組共分為6組。應(yīng)用不銹鋼模具制成圓柱體標(biāo)準(zhǔn)試件,于萬能試驗(yàn)機(jī)上以20 mm/min的速度對試件施加壓應(yīng)力,試件破壞時(shí)計(jì)算機(jī)自動(dòng)輸出最大載荷數(shù)據(jù)。骨水泥板條放入萬能力學(xué)機(jī)后,測量彎曲強(qiáng)度和彎曲模量。結(jié)果隨著慶大霉素添加劑量的增加(即1.0 g→2.0 g),慶大霉素骨水泥的釋放逐漸增多,各水平慶大霉素骨水泥的壓縮強(qiáng)度、彎曲模量、彎曲強(qiáng)度逐漸減少。隨著添加木糖醇劑量的增加(即11 g→22 g),骨水泥慶大霉素的釋放逐漸增多,并能延續(xù)4周以上,慶大霉素骨水泥的壓縮強(qiáng)度、彎曲模量、彎曲強(qiáng)度沒有顯著改變。結(jié)論添加木糖醇并不會(huì)顯著影響慶大霉素骨水泥的力學(xué)性能,能有效促進(jìn)慶大霉素從骨水泥中持續(xù)釋放。
[Abstract]:Objective to investigate the effect of xylitol additive on the in vitro release and biomechanics of gentamicin bone cement by measuring the antibiotic release and biomechanical strength of gentamicin bone cement at different time points. To provide experimental basis for clinical application of antibiotic bone cement. Methods 40 g of antibiotic bone cement was added with 11 and 22 g xylitol and divided into 6 groups. The cylinder standard specimen was made by using stainless steel mould. The compressive stress was applied to the specimen at a speed of 20 mm/min on the universal testing machine. The computer automatically output the maximum load data when the specimen was destroyed. The bending strength and modulus were measured after the bone cement strip was put into the universal mechanical machine. Results with the increase of the amount of gentamicin additive (1.0 g / 2. 0 g), the release of gentamicin bone cement gradually increased, and the compression strength, flexural modulus and bending strength of gentamicin bone cement decreased gradually. With the increase of the dosage of xylitol (11 g / 22 g), the release of gentamicin increased gradually and lasted for more than 4 weeks. The compressive strength, flexural modulus and flexural strength of gentamicin bone cement did not change significantly. Conclusion the addition of xylitol can not significantly affect the mechanical properties of gentamicin bone cement, but can effectively promote the sustained release of gentamicin from bone cement.
【作者單位】： 西安醫(yī)學(xué)院第一附屬醫(yī)院;西安交通大學(xué)第二附屬醫(yī)院;
【分類號(hào)】：R318.01

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