本文選題：殼聚糖 + 聚丙烯類　； 參考：《中國組織工程研究》2017年26期

【摘要】：背景:研究顯示,殼聚糖能提高纖維細(xì)胞增殖、遷移速度,促進(jìn)細(xì)胞外基質(zhì)的合成,能為缺損部位營造良好的愈合環(huán)境。目的:觀察高仿真殼聚糖支架修復(fù)大鼠腹壁缺損的效果。方法:取成年SD大鼠60只,建立腹壁缺損模型,隨機(jī)分2組修復(fù),實(shí)驗(yàn)組于缺損部位植入高仿真殼聚糖支架,對照組植入聚丙烯補(bǔ)片,修復(fù)后2,4周,進(jìn)行修復(fù)部位大體、粘連及病理組織學(xué)觀察。結(jié)果與結(jié)論:(1)大體觀察:對照組修復(fù)后2周缺損部位與網(wǎng)膜存在粘連現(xiàn)象,修復(fù)4周后補(bǔ)片部位明顯增厚,與周圍組織界限比較清晰,補(bǔ)片區(qū)域色澤一般,整合一般;實(shí)驗(yàn)組修復(fù)2周后缺損部位與支架輕微粘連,修復(fù)后4周補(bǔ)片增厚,缺損部位未見明顯隆起、紅腫、感染,傷口愈合較好;(2)粘連:實(shí)驗(yàn)組修復(fù)后4周Kadata粘連評分低于對照組(P0.05);(3)病理組織學(xué)觀察:對照組修復(fù)4周后可見毛細(xì)血管生長,存在大量的成纖維細(xì)胞,缺損部位存在大量炎細(xì)胞浸潤;實(shí)驗(yàn)組修復(fù)4周后可見少許炎癥細(xì)胞,存在大量膠原纖維、毛細(xì)血管,肉芽組織成熟度較高;(4)結(jié)果表明:高仿真殼聚糖支架可促進(jìn)缺損腹壁的修復(fù),減輕炎性反應(yīng)。
[Abstract]:Background: chitosan can improve the proliferation and migration of fibroblasts, promote the synthesis of extracellular matrix, and create a good healing environment for the defect site. Objective: to observe the effect of high-simulated chitosan scaffold in repairing abdominal wall defect in rats. Methods: 60 adult SD rats were selected to establish abdominal wall defect model, and were randomly divided into 2 groups. The experimental group implanted high simulated chitosan scaffold in the defect site, the control group implanted polypropylene patch, 2 weeks after repair, the repair site was gross. Adhesion and histopathological observation. Results and conclusion: in the control group, there was adhesion between the defect and omentum 2 weeks after repair. After 4 weeks of repair, the patch was thickened, and the boundary between the patch and the surrounding tissue was clear, the color of the patch was general and the integration was general. In the experimental group, there was slight adhesion between the defect site and the stent 2 weeks after repair, and the thickness of the patch increased 4 weeks after repair. No significant swelling, swelling and infection were found in the defect site. The Kadata adhesion score in the experimental group was lower than that in the control group at 4 weeks after repair (P 0.05). Histopathological observation: capillary growth was observed in the control group after 4 weeks of repair, and a large number of fibroblasts were found in the experimental group. There were a large number of inflammatory cells infiltrating in the defect site, a few inflammatory cells were found in the experimental group after 4 weeks of repair, and a large number of collagen fibers and capillaries were found in the experimental group. The results showed that high imitated chitosan scaffold could promote the repair of the abdominal wall and alleviate the inflammatory reaction.
【作者單位】： 青海省腫瘤醫(yī)院;河北醫(yī)科大學(xué)第三醫(yī)院;
【基金】：河北省科技廳項(xiàng)目(20110426)~~
【分類號】：R318.08;R656

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