發(fā)布時(shí)間：2018-05-11 08:45

  本文選題：生物相容性材料 + 支架��； 參考：《中國(guó)組織工程研究》2017年14期

【摘要】：背景:骨組織工程在骨缺損修復(fù)方面起著非常重要的作用,可呈遞生物活性物質(zhì),促進(jìn)骨組織生長(zhǎng),進(jìn)而修復(fù)骨缺損,其中,支架是骨組織工程的三要素之一,3D打印技術(shù)可以實(shí)現(xiàn)骨組織修復(fù)的個(gè)體化治療,從而個(gè)性化定制人工骨。目的:分析幾種常用的骨組織工程支架材料的生物學(xué)特性,探討3D打印技術(shù)在骨組織工程支架構(gòu)建中的應(yīng)用。方法:通過(guò)檢索2005至2016年P(guān)ub Med和萬(wàn)方數(shù)據(jù)庫(kù)有關(guān)骨組織工程支架材料和3D打印技術(shù)應(yīng)用的相關(guān)文獻(xiàn)。以"組織工程支架,骨缺損,高分子材料,陶瓷材料,金屬材料,復(fù)合材料,3D打印"為中文檢索詞,"Tissue Engineering Scaffold,bone defects,polymer materials,Bioceramics,Metal Materials,Composite Materials,3D printing"為中文檢索詞,檢索摘要內(nèi)同時(shí)包含上述檢索詞的文獻(xiàn),排除重復(fù)性研究,最終納入65篇文獻(xiàn)進(jìn)一步分析。結(jié)果與結(jié)論:(1)目前常用的骨組織工程支架材料包括聚合物材料(如天然聚合物材料和高分子聚合物材料)、生物陶瓷和金屬材料等,根據(jù)材料的特性將不同材料復(fù)合可以彌補(bǔ)單一材料的缺點(diǎn),并制備新型的組織工程支架材料;(2)用于組織工程骨制作的3D打印技術(shù)包括熔融沉積技術(shù)、選擇性激光燒結(jié)技術(shù)、低溫沉積制造技術(shù)等;(3)3D打印應(yīng)用于骨組織工程支架構(gòu)建時(shí),所用的粉末或黏合劑需具備一定的條件,如流動(dòng)性、穩(wěn)定性與可濕性等;用于打印的粉末材料可分為人工合成多聚體、天然高分子聚合物、生物陶瓷及它們的混合物;不同粉末材料的粉末各自優(yōu)缺點(diǎn)不同,且最終成型效果也不盡相同;(4)3D打印技術(shù)制作的骨組織工程支架在力學(xué)、結(jié)構(gòu)、個(gè)性化方面有其獨(dú)特的優(yōu)勢(shì),在骨支架制造方面有廣泛的應(yīng)用前景。
[Abstract]:Background: bone tissue engineering plays an important role in the repair of bone defects. It can present bioactive substances, promote bone tissue growth, and then repair bone defects. Scaffold is one of the three elements of bone tissue engineering. Aim: to analyze the biological characteristics of several bone tissue engineering scaffolds and discuss the application of 3D printing technology in the construction of bone tissue engineering scaffolds. Methods: by searching Pub Med and Wanfang database from 2005 to 2016, relevant literatures on scaffold materials and 3D printing technology of bone tissue engineering were searched. "tissue engineering scaffold, bone defect, polymer material, ceramic material, metal material, composite material 3D print" is used as the Chinese key word, "Tissue Engineering Scaffoldbone defenses / polymer material" as the Chinese key word. Repetitive studies were excluded and 65 articles were included for further analysis. Results and conclusion at present, bone tissue engineering scaffold materials commonly used include polymer materials (such as natural polymer materials and polymer materials, bioceramics and metal materials, etc.) According to the characteristics of materials, different materials can make up for the shortcomings of a single material, and a new type of tissue engineering scaffold material, Jianyu 2, is prepared. The 3D printing techniques used in tissue engineering bone fabrication include melt deposition technology, selective laser sintering technology, and so on. When the low temperature deposition manufacturing technology is used in the construction of bone tissue engineering scaffolds, the powder or adhesive must have certain conditions, such as fluidity, stability and wettability. The powder materials used for printing can be divided into synthetic polymers, natural polymer polymers, bioceramics and their mixtures. The final molding effect is also different. The bone tissue engineering scaffold made by 3D printing technology has its unique advantages in mechanics, structure and individuation, and has a wide application prospect in the manufacture of bone scaffold.
【作者單位】： 邢臺(tái)醫(yī)學(xué)高等�？茖W(xué)校;承德醫(yī)學(xué)院應(yīng)用心理學(xué)系;邢臺(tái)醫(yī)學(xué)高等專科學(xué)校第二附屬醫(yī)院;河北醫(yī)科大學(xué)附屬邢臺(tái)市人民醫(yī)院;山西博愛醫(yī)院;
【基金】：河北省中醫(yī)藥管理局資助項(xiàng)目(2012068)~~
【分類號(hào)】：R318.08;R683

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