本文選題：多孔鉭 + 組織相容性　； 參考：《南京醫(yī)科大學學報(自然科學版)》2014年05期

【摘要】：目的:觀察國產(chǎn)多孔鉭材料的三維孔隙結(jié)構(gòu)以及兔豎脊肌植入后組織形態(tài)學特點,對其組織相容性進行評價,為臨床骨缺損修復重建提供實驗依據(jù)。方法:掃描電鏡觀察國產(chǎn)多孔鉭結(jié)構(gòu);成年新西蘭大白兔24只,建立多孔鉭兔豎脊肌植入動物模型。將2枚直徑1.5 cm、厚0.2 cm圓型多孔鉭植入脊柱一側(cè)豎脊肌內(nèi)(實驗組),對側(cè)植入同等數(shù)量及體積的多孔鈦(對照組)。于術(shù)后2、4、8、12周處死行硬組織切片觀察肌肉周圍纖維包膜及新生血管形成,并計算小血管生成數(shù)量;掃描電鏡觀察肌肉組織在兩種材料內(nèi)的生長狀態(tài)。結(jié)果:掃描電鏡觀察多孔鉭具有三維立體多孔結(jié)構(gòu),孔隙直徑在400~600μm;肌肉及纖維組織早期在多孔鉭表面及孔隙內(nèi)生長;晚期膠原纖維延展,相互連接并充滿孔隙。硬組織切片顯示:隨時間的延長多孔鉭-肌肉界面形成薄而致密的血管化包膜�？紫秲�(nèi)充滿肌肉、纖維組織及小血管。結(jié)論:國產(chǎn)多孔鉭材料具有良好的組織相容性,其三維結(jié)構(gòu)可使肌肉組織在表面及孔隙內(nèi)生長及延伸,有可能成為骨缺損修復材料。
[Abstract]:Objective: to observe the three-dimensional pore structure of porous tantalum and the histomorphological characteristics of rabbit erector spinal muscle after implantation, and to evaluate its histocompatibility in order to provide experimental basis for clinical bone defect repair and reconstruction.Methods: the structure of porous tantalum in China was observed by scanning electron microscope, and 24 adult New Zealand white rabbits were used to establish the animal model of erector spinal muscle implantation in porous tantalum rabbits.Two porous tantalum with a diameter of 1.5 cm and a thickness of 0.2 cm were implanted into one side of the spinal column (experimental group) and the contralateral side were implanted with the same amount and volume of porous titanium (control group).At 12 weeks after operation, the perimuscular fibrous capsule and neovascularization were observed by hard tissue section, and the number of small angiogenesis was calculated, and the growth state of muscle tissue in the two materials was observed by scanning electron microscope.Results: the porous tantalum had a three-dimensional porous structure with pore diameter of 400 ~ 600 渭 m. The muscle and fibrous tissue grew on the surface and pore of porous tantalum in the early stage, and the collagen fibers were extended, connected and filled with pores in the late stage.The hard tissue section showed that the porous tantalum-muscle interface formed a thin and dense vascularized capsule with time.The pores are filled with muscles, fibrous tissue and small blood vessels.Conclusion: porous tantalum made in China has good histocompatibility, and its three-dimensional structure can make muscle tissue grow and extend in the surface and pore, which may be used as bone defect repair material.
【作者單位】： 河北聯(lián)合大學附屬醫(yī)院骨科;唐山開灤總醫(yī)院檢驗科;河北聯(lián)合大學臨床醫(yī)學院;河北聯(lián)合大學實驗中心;河北聯(lián)合大學基礎(chǔ)醫(yī)學院解剖教研室;
【基金】：國家科技部科技支撐項目(2012BAE06B03)
【分類號】：R318.08

【參考文獻】

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