本文選題：慢性阻塞性肺疾病 + 氣道測(cè)量��； 參考：《中南大學(xué)》2012年碩士論文

【摘要】：慢性阻塞性肺疾病COPD是一種嚴(yán)重危害人類健康的疾病�；诙SCT圖像的胸腔內(nèi)氣道高精度幾何測(cè)量對(duì)COPD患者的診斷和治療具有重要意義。 半高寬法是目前通用的氣道幾何尺寸測(cè)量法,但該方法只在測(cè)量大、厚且垂直CT成像平面的氣道時(shí)才能獲得較理想的效果,并不適用于所有尺寸氣道的測(cè)量。 為改善小氣道的幾何測(cè)量精度,本文采用一種基于CT成像過程的數(shù)學(xué)模型的參數(shù)擬合法。該方法首先利用Bresenham算法檢查穿過氣道壁射線的灰度值,得到射線的真實(shí)灰度輪廓；然后構(gòu)建模擬CT模糊的數(shù)學(xué)模型；最后通過Levenberg-Marquardt算法對(duì)模擬灰度輪廓和真實(shí)灰度輪廓進(jìn)行擬合,從而得到最接近于真實(shí)灰度輪廓的模型參數(shù)估計(jì)—?dú)獾赖膬?nèi)、外徑估計(jì)。本文方法對(duì)CT成像過程中引入的模糊進(jìn)行了建模,適用于不同尺寸氣道的幾何測(cè)量。 為了驗(yàn)證本文方法的有效性,利用蒙特卡洛投影仿真工具包(V4r2.3.2)對(duì)7個(gè)不同管徑的二維理想環(huán)狀氣道模型進(jìn)行仿真,然后分別使用半高寬法和本文方法來測(cè)量仿真圖形。結(jié)果表明,在測(cè)量小、薄壁氣道模型時(shí),本文方法具有較高的測(cè)量精度和穩(wěn)定性。將兩種方法分別應(yīng)用于15例COPD患者RB1吸氣相3-5級(jí)氣道胸部CT圖像的氣道測(cè)量實(shí)驗(yàn)。結(jié)果表明,兩種方法測(cè)量結(jié)果的差異主要存在于5級(jí)氣道的測(cè)量中,且本文方法能得到比半高寬法更穩(wěn)定的測(cè)量結(jié)果。
[Abstract]:Chronic obstructive pulmonary disease (COPD) is a serious disease that endangers human health.High precision geometry measurement of thoracic airway based on two-dimensional CT images is of great significance for the diagnosis and treatment of COPD patients.Half-height width method is a universal method for measuring the geometry of airways. However, the method can only obtain ideal results when measuring the airways with large, thick and vertical CT imaging plane, and is not suitable for the measurement of all sizes of airways.In order to improve the geometric measurement accuracy of small airway, a parameter fitting method based on the mathematical model of CT imaging process is used in this paper.The method firstly uses Bresenham algorithm to check the gray value of the ray through the airway wall to get the real gray contour of the ray. Then the mathematical model of simulating CT fuzzy is constructed. Finally, the simulated gray contour and the real gray contour are fitted by the Levenberg-Marquardt algorithm.Thus, the model parameter estimation which is closest to the real gray contour is obtained-the inner and outer diameter estimation of the airway.In this paper, the fuzzy model introduced in CT imaging process is modeled, which is suitable for geometric measurement of different sizes of airways.In order to verify the effectiveness of the proposed method, seven 2-D ideal annular channel models with different pipe diameters are simulated by Monte Carlo projection simulation toolkit (V4r2.3.2), and then the half-height width method and the present method are used to measure the simulation figures respectively.The results show that the proposed method has high measurement accuracy and stability when the model is small and thin-walled.The two methods were used to measure the airway of 15 cases of COPD patients with RB1 inspiratory phase 3-5 stage CT images of airway chest.The results show that the difference between the two methods is mainly in the measurement of 5-stage airways, and the results obtained by this method are more stable than that of the half-high width method.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R311

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