本文選題：生物陶瓷　切入點(diǎn)：宏觀孔隙結(jié)構(gòu)　出處：《西南交通大學(xué)》2017年碩士論文

【摘要】：磷酸鈣生物陶瓷材料因具有良好的生物相容性而廣泛應(yīng)用于人工骨替代材料。研究表明,在磷酸鈣陶瓷骨誘導(dǎo)性潛能中發(fā)揮作用的材料特性包括化學(xué)成分,宏觀結(jié)構(gòu)特征和微觀結(jié)構(gòu)特征。特別是針對磷酸鈣植入材料的宏觀結(jié)構(gòu)與骨誘導(dǎo)性之間的相關(guān)性方面,盡管有大量的實(shí)驗(yàn)研究數(shù)據(jù),但實(shí)驗(yàn)研究方法耗時長,成本高,誤差大,而且缺乏對其機(jī)制系統(tǒng)性的理解,這限制了生物陶瓷在臨床骨缺損治療中的廣泛應(yīng)用。此外,大量的動物實(shí)驗(yàn)結(jié)果和體外培養(yǎng)組織工程構(gòu)建體的研究都顯示了微流體動力環(huán)境對支架內(nèi)細(xì)胞生物功能活性具有重要影響,種種跡象表明孔隙結(jié)構(gòu)很可能作為力學(xué)信號轉(zhuǎn)化載體在材料骨誘導(dǎo)發(fā)生機(jī)制中發(fā)揮作用。故本論文基于生物力學(xué)理論,從宏觀孔隙結(jié)構(gòu)、體內(nèi)動態(tài)環(huán)境和細(xì)胞力學(xué)刺激的相關(guān)性入手,利用對多孔支架仿真建模和有限元分析的方法,研究多孔支架的宏觀結(jié)構(gòu)特征與骨誘導(dǎo)性之間的相關(guān)性。并對多孔支架結(jié)構(gòu)的優(yōu)化設(shè)計(jì)提供理論依據(jù)。主要內(nèi)容如下:(1)用Micro-CT的方法對制備的多孔支架進(jìn)行孔隙參數(shù)分析和結(jié)構(gòu)特征和趨勢的提取。結(jié)果表明,多孔支架孔隙結(jié)構(gòu)趨于六方密堆結(jié)構(gòu),基于此結(jié)構(gòu),利用SolidWorks軟件構(gòu)建了多孔支架的簡化計(jì)算模型以用于后續(xù)有限元分析。根據(jù)所構(gòu)建出的等效簡化模型,研究了多孔支架的貫通孔/宏孔的比例極限問題。得到結(jié)論為貫通孔/宏孔的尺寸比例范圍在0～0.5之間,比例下限為0,上限為0.5,當(dāng)超出此上限時,支架結(jié)構(gòu)出現(xiàn)破損缺陷。(2)用ANSYS軟件構(gòu)建了多孔支架的力學(xué)模型,模擬得到了多孔支架的壓力位移曲線,得到理想的多孔支架的力學(xué)特性曲線是呈線性分布。并用實(shí)驗(yàn)測量得到的壓力位移曲線數(shù)據(jù),通過兩者的對比分析,研究多孔支架的力學(xué)特性,從理論力學(xué)方面入手驗(yàn)證了構(gòu)建的等效模型可作為實(shí)際支架的替代計(jì)算模型。(3)用F1ow simulation軟件對不同宏觀結(jié)構(gòu)特征的多孔支架模型內(nèi)的微流體動力環(huán)境進(jìn)行仿真模擬,得到了不同宏觀結(jié)構(gòu)特征的流場分布圖和內(nèi)部的剪切應(yīng)力數(shù)據(jù),通過對數(shù)據(jù)的對比分析和理論研究并結(jié)合課題組前期的動物實(shí)驗(yàn)結(jié)果,得到結(jié)論為宏孔和貫通孔的尺寸對多孔支架材料的成骨性能有顯著影響,并且這種影響是宏孔和貫通孔相互協(xié)同基于對微流體動力環(huán)境的作用后的結(jié)果。研究結(jié)論還提示材料宏觀結(jié)構(gòu)因素極有可能是通過微流體動力途徑轉(zhuǎn)化為生物功能化調(diào)控信號來影響生物陶瓷的骨誘導(dǎo)性。
[Abstract]:Calcium phosphate bioceramics are widely used as substitute materials for artificial bone because of their good biocompatibility.The results show that the properties of the materials that play an important role in the osteoinductive potential of calcium phosphate ceramics include chemical composition, macroscopic structure and microstructure.In particular, in view of the correlation between the macrostructure of calcium phosphate implant material and bone inductivity, although there are a lot of experimental data, the experimental research methods take a long time, high cost and large error.And the lack of systematic understanding of its mechanism limits the wide application of bioceramics in the treatment of bone defects.In addition, a large number of animal experiments and studies of tissue engineering constructions in vitro have shown that the microhydrodynamic environment has an important effect on the biological activity of cells in the scaffold.It is suggested that the pore structure may play an important role in the mechanism of bone induction as a carrier of mechanical signal transformation.Therefore, based on the biomechanical theory, this paper starts with the correlation of macro pore structure, dynamic environment in vivo and cellular mechanical stimulation, and uses the method of simulation modeling and finite element analysis of porous scaffold.To study the correlation between macrostructural characteristics and bone inductivity of porous scaffolds.It also provides the theoretical basis for the optimization design of the porous scaffold structure.The main contents are as follows: (1) the porous scaffolds were analyzed by Micro-CT method and the structure characteristics and trends were extracted.The results show that the pore structure of porous scaffold tends to be hexagonal dense stack structure. Based on this structure, a simplified calculation model of porous scaffold is constructed by using SolidWorks software for subsequent finite element analysis.Based on the equivalent simplified model, the problem of the ratio limit of the perforation hole to the macro hole of the porous scaffold is studied.It is concluded that the size ratio of the through hole to the macro hole is between 0 and 0.5, the ratio lower limit is 0 and the upper limit is 0.5. When the upper limit is exceeded, there is a damage defect in the support structure. The mechanical model of the porous support is constructed by using ANSYS software.The pressure and displacement curves of porous scaffolds were obtained by simulation, and the ideal mechanical characteristics curves of porous scaffolds were obtained with linear distribution.The mechanical properties of the porous scaffold were studied by comparing and analyzing the pressure and displacement curves measured by experiments.From the aspect of theoretical mechanics, it is verified that the constructed equivalent model can be used as a substitute calculation model for practical scaffolds. The microhydrodynamic environment in porous scaffold models with different macroscopic structural characteristics is simulated by F1ow simulation software.The distribution map of flow field and the internal shear stress data of different macroscopic structural characteristics are obtained. Through the comparative analysis and theoretical study of the data, combined with the experimental results of animal experiments in the earlier period of the research group, the flow field distribution map and the internal shear stress data are obtained.It is concluded that the size of macroporous and perforated pores has a significant effect on the osteogenic properties of porous scaffolds, and this effect is the result of the interaction between macropores and perforated pores based on the microhydrodynamic environment.The results also suggest that the macrostructure of the material may be changed into the biological functionalized regulatory signal through the microhydrodynamic pathway to influence the bone induction of bioceramics.
【學(xué)位授予單位】：西南交通大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R318.08

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 季僑丹;何成奇;;不同機(jī)械力學(xué)刺激對骨成骨作用的研究進(jìn)展[J];中國骨傷;2016年04期

2 陶飛飛;吳繼功;馬華松;宋淑軍;劉俊麗;邵水霖;張樂樂;陶有平;高博;李海俠;;變頻振動在模擬微重力環(huán)境下對成骨細(xì)胞增殖和分化的影響[J];中國骨質(zhì)疏松雜志;2014年05期

3 趙婧;李金雨;智偉;魯雄;賈治彬;翁杰;;蠟球造孔法制備多孔HA陶瓷支架及其性能優(yōu)化[J];無機(jī)材料學(xué)報(bào);2013年01期

4 王麗麗;黨新安;楊立軍;齊艷梅;;人工骨支架內(nèi)部微結(jié)構(gòu)兩相流數(shù)值模擬[J];機(jī)械設(shè)計(jì)與制造;2012年07期

5 郭來陽;張靖微;趙婧;汪建新;翁杰;張聰;;具有良好貫通性的顆粒造孔支架的制備及表征[J];無機(jī)材料學(xué)報(bào);2011年01期

6 趙婧;魯雄;汪建新;翁杰;;具有生物活性的多孔鈦金屬復(fù)合支架的制備[J];生物醫(yī)學(xué)工程學(xué)雜志;2009年04期

7 鄧超;陳彰旭;謝曙光;金雪玲;王雪婷;廖洪林;;納米羥基磷灰石應(yīng)用研究進(jìn)展[J];廣東化工;2009年03期

8 趙康;魏俊琪;羅德福;湯玉斐;徐雷;;冷凍干燥法制備羥基磷灰石多孔支架[J];硅酸鹽學(xué)報(bào);2009年03期

9 劉洪麗;鐘文武;宋春梅;鄭智敏;;采用聚硅氮烷制備SiCN泡沫陶瓷[J];稀有金屬材料與工程;2007年S1期

10 梁偉;茍三懷;齊進(jìn);魏立;歐陽躍平;劉巖;;低強(qiáng)度脈沖超聲波對體外培養(yǎng)的兔骨髓基質(zhì)細(xì)胞成骨作用的影響[J];第二軍醫(yī)大學(xué)學(xué)報(bào);2007年06期

相關(guān)博士學(xué)位論文 前1條

1 劉玲蓉;用于骨組織再生修復(fù)的膠原-HA復(fù)合材料的應(yīng)用基礎(chǔ)研究[D];中國協(xié)和醫(yī)科大學(xué);2007年

相關(guān)碩士學(xué)位論文 前2條

1 馬哲一;骨組織工程支架內(nèi)微流體流動狀態(tài)的數(shù)值仿真及分析[D];燕山大學(xué);2009年

2 陳紅波;基于快速成型的組織工程中流動現(xiàn)象的研究[D];燕山大學(xué);2007年

，

本文編號：1722594