本文選題：合成生物學　切入點：光遺傳學　出處：《中國科學:生命科學》2017年05期 　論文類型：期刊論文

【摘要】：光遺傳學是一項整合了光學、基因操作技術、電生理等多學科交叉的具有高度時空特異性、低毒性的生物工程技術.目前已經實現了從時空上控制細胞活動并用于疾病的治療.本文將重點介紹近些年光遺傳學裝置在生物醫(yī)學上的應用,闡明光遺傳裝置用于疾病治療的構建和機制.此外,本文還簡要探討了光控基因裝置在實際臨床治療應用中的前景和挑戰(zhàn).
[Abstract]:Optogenetics is a highly space-time specific combination of optics, gene manipulation techniques, electrophysiology, and so on. Low toxicity bioengineering technology. At present, we have realized the control of cell activity in time and space and used in the treatment of diseases. This paper will focus on the application of photogenetic devices in biomedicine in recent years. The construction and mechanism of photogenetic devices for the treatment of diseases are expounded. In addition, the prospect and challenges of photo-controlled gene devices in clinical treatment are also briefly discussed.
【作者單位】： 華東師范大學生命科學學院上海市調控生物學重點實驗室;
【基金】：國家科技部重大研究計劃(批準號:2016YFA0100302) 國家自然科學基金(批準號:31470834,31522017,31670869) 上海市科學技術委員會項目(批準號:15QA1401500,14JC1401700) “青年千人計劃”資助
【分類號】：R318.0
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本文編號：1567410