本文關(guān)鍵詞： GBR bio-oss β-磷酸三鈣 CBCT 生物力學(xué)　出處：《瀘州醫(yī)學(xué)院》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：種植修復(fù)已成為臨床缺失牙修復(fù)的一種常用方式，應(yīng)用較為廣泛。而種植區(qū)良好的骨條件是種植術(shù)成功的首要因素，但臨床上骨質(zhì)缺損、骨量不足的情況占大多數(shù)，需要進(jìn)行骨增量來(lái)解決。近年來(lái)國(guó)內(nèi)外對(duì)于引導(dǎo)骨再生技術(shù)(Guided bone regeneration GBR)的研究較多，包括各種影像學(xué)、組織學(xué)檢測(cè)和多種材料的研究，其成骨效果已得到普遍認(rèn)可，并已在臨床廣泛開(kāi)展。但此技術(shù)引導(dǎo)的新生骨的生物力學(xué)性能的研究很少，本實(shí)驗(yàn)通過(guò)對(duì)不同時(shí)期不同材料引導(dǎo)的新生骨的生物力學(xué)性能研究，為新生骨成骨的質(zhì)量、密度及各種生物力學(xué)參數(shù)得出結(jié)論，從而為臨床種植時(shí)間及植骨材料的選擇等提供參考數(shù)據(jù)。 方法：以12只成年Beagle犬為對(duì)象，分別在其雙側(cè)股骨髁預(yù)備3個(gè)6mm直徑10mm高的圓柱形骨缺損，分別行GBR術(shù)，植入Bio-oss骨粉（B組）、β-磷酸三鈣(β-TCP β-tricalcium phosphate)骨粉（C組）及自體骨屑（Z組）。術(shù)后三個(gè)月和六個(gè)月分別處死6只實(shí)驗(yàn)犬，取樣制作各組標(biāo)本。左側(cè)三組標(biāo)本進(jìn)行錐形束CT（CBCT）掃描，觀察成骨情況，比較各組新生骨骨密度；CBCT檢測(cè)后的標(biāo)本進(jìn)行骨壓縮試驗(yàn)，檢測(cè)新生骨塊的抗壓能力；右側(cè)標(biāo)本行種植手術(shù)，檢測(cè)即刻扭矩；之后進(jìn)行骨塊推出實(shí)驗(yàn)，檢測(cè)新生骨與自然骨結(jié)合界面的抗剪切力。 結(jié)果：本實(shí)驗(yàn)成功建立了動(dòng)物模型并制作了各組標(biāo)本。在此基礎(chǔ)上進(jìn)行CT檢測(cè)顯示各組均有成骨，且6個(gè)月比3個(gè)月時(shí)骨密度高。壓縮實(shí)驗(yàn)顯示各組6個(gè)月組的抗壓能力均優(yōu)于3個(gè)月組；3個(gè)月組內(nèi)，抗壓能力Z組B組C組；6個(gè)月組內(nèi)Z組C組、B組C組、Z組和B組無(wú)差異。扭矩測(cè)試顯示，3個(gè)月組和6個(gè)月組內(nèi)B組和Z組均無(wú)差異，，且都大于C組；平均扭矩只有3個(gè)月組的C組30N/cm，其它組均30N/cm。推出實(shí)驗(yàn)顯示3個(gè)月組和6個(gè)月組內(nèi)B組剪切力均大于C組；B組和C組各自剪切力比較6個(gè)月組均大于3個(gè)月組。 結(jié)論：bio-oss引導(dǎo)的新生骨與β-TCP引導(dǎo)的新生骨比較，其抗壓能力更強(qiáng)，能為種植體提供更好的初期穩(wěn)定作用，且在與自然骨的結(jié)合能力上更具優(yōu)勢(shì)。
[Abstract]:Objective: implant restoration has become a common method of clinical restoration of missing teeth and has been widely used. Good bone condition in implant area is the primary factor for success of implant, but clinical bone defect is one of the most important factors. Lack of bone mass is the majority. In recent years, there are many researches on guided bone regeneration (GBR), including all kinds of imaging, in order to solve the problem of bone increment. The effect of osteogenesis has been widely accepted and widely carried out in clinic, but the biomechanical properties of new bone guided by this technique are few. In this experiment, the biomechanical properties of new bone guided by different materials at different periods were studied, and the conclusion was drawn for the quality, density and biomechanical parameters of new bone osteogenesis. So as to provide reference data for clinical implant time and selection of bone graft materials. Methods: 12 adult Beagle dogs were used to prepare 3 cylindrical bone defects with 6mm diameter and 10mm height in their bilateral femoral condyles. GBR was performed respectively. Bio-oss bone powder group B). 尾 -TCP 尾 -tricalcium phosphate (尾 -TCP 尾 -tricalcium phosphate bone powder group C) and autogenous bone scraps group Z). 6 dogs were killed 3 and 6 months after operation. The left three groups of specimens were scanned by CT-CBCT to observe the osteogenesis and compare the bone density of new bone in each group. The bone compression test was performed on the specimens detected by CBCT, and the compressive capacity of the new bone was tested. The right specimens were implanted and the instant torque was detected. Then the bone block extrapolation experiment was carried out to detect the shear resistance of the interface between the new bone and the natural bone. Results: the animal model was successfully established and the specimens of each group were made. On the basis of this, CT examination showed that osteogenesis was found in all groups. The compression test showed that the anti-compression ability of the 6-month group was better than that of the 3-month group. Within 3 months, the ability to resist pressure in group Z, group B, group C; There was no difference between group Z and group B in 6 months. Torque test showed that there was no difference between group B and group Z in 3-month group and 6-month group, which was higher than that in group C; The mean torque was only 30 N / cm in group C and 30 N / cm in other groups. The results showed that the shear force of group B was higher than that of group C in 3 months and 6 months. The shear forces of group B and group C were higher than that of group 3. Conclusion compared with 尾 -TCP guided newborn bone, the new bone guided by the weight bio-oss has stronger anti-compression ability and can provide better initial stabilization for implants. Moreover, it has more advantages in the ability of combining with natural bone.
【學(xué)位授予單位】：瀘州醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R783.1

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