In order to explore the evidence of transient neuronal plasticity observed in human sensorimotor cortex during development of learning, the mechanisms of activity-dependent synaptic modification in cultured cortical sensorimotor neurons in rats were studied. Long-term potentiation （LTP） is an activity-dependent strengthening of synaptic efficacy that is considered to be one of indexes of learning and memory in the present study. Voltage pulse, as a model of repetitive electrical stimulation, was... 

【文章來源】：中國人民解放軍軍事科學(xué)院北京市

【文章頁數(shù)】：75 頁

【學(xué)位級別】：博士

【文章目錄】：
Abstract
Introduction
Experimental procedures
    Ⅰ． Cell culture
    Ⅱ． Solutions
    Ⅲ． Electrophysiology
    Ⅳ． Data analysis and statistics
Results
    Ⅰ． Cortical sensorimotor neurons in VLD cultures
    Ⅱ． Voltage-gated ionic channels
    Ⅲ． Spontaneous neuronal activity of cortical sensorimotor neuron
    Ⅳ． Properties of spontaneous EPSCs of cortical sensorimotor neurons
    Ⅴ． Voltage-pulses potentiate spontaneouse neuronal activity
    Ⅵ． NMDA application potentiates synaptic transmission
Discussion
Summary
References
Acknowledgement
Abbreviations
List of publications


【參考文獻】：
期刊論文
[1]乙酰膽堿對培養(yǎng)大鼠皮層神經(jīng)元興奮性及抑制性突觸電流的相反作用[J]. 劉青松,何湘平,劉傳繢.  生理學(xué)報. 1996(04)



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