本文選題：胃電圖 + 胃電活動�。� 參考：《揚州大學(xué)》2010年碩士論文

【摘要】： 胃的電機械活動是胃完成其正常生理功能的基礎(chǔ)。多年來對胃的電機械活動的研究、建模和仿真已經(jīng)有很多結(jié)果,但是,我們還沒有看到胃電機械活動傳播的模型及其三維動態(tài)模擬的相關(guān)報道。本論文的主要工作是分析胃電活動模型,建立胃電活動傳導(dǎo)和蠕動收縮傳播的三維模型,進而對其進行三維動態(tài)模擬。 在闡述胃電機械活動的產(chǎn)生、特點及功能的基礎(chǔ)上,本文首先用Matlab對離子機制的電活動模型進行分析和模擬,總結(jié)出不同類型細胞電活動的規(guī)律和特性,然后研究和模擬了電活動傳導(dǎo)模型,最后建立了胃電機械活動關(guān)系和傳播模型,并成功實現(xiàn)了用Matlab對胃的電機械活動的三維動態(tài)模擬。本文著重論述了逼近真實胃形態(tài)的三維胃模型和胃電機械活動耦合傳播模型的建立及其Matlab模擬。 本文用Matlab對傳統(tǒng)離子機制的電活動模型H-H模型和FHN模型進行數(shù)學(xué)分析,并用圖象來展示其電活動規(guī)律,通過比較和分析,總結(jié)出ICC細胞和平滑肌細胞之間不同的電活動規(guī)律和特性。分析模擬的結(jié)果不僅增進了我們對ICC細胞和平滑肌細胞功能作用的理解和認識,而且證明了這些胃電模型的合理性。 本文對較成功的胃電活動傳導(dǎo)的錐形體模型和柱導(dǎo)體模型進行研究,分析了電活動傳導(dǎo)的規(guī)律。本文用這些模型建立的方法和原則建立了新的漿膜慢波傳導(dǎo)模型,并用Matlab進行仿真。仿真結(jié)果反應(yīng)了胃電活動傳播規(guī)律,證實了傳導(dǎo)模型的可靠性。 本文首次實現(xiàn)了用Matlab建立和模擬了接近真實胃形態(tài)的三維胃模型。為了實現(xiàn)三維胃模型盡可能接近真實胃形態(tài),我們用多個變形錐形體(或者柱形體)組合逼近靜態(tài)胃形態(tài),從而建立了靜態(tài)胃的三維模型。我們詳細闡述了三維胃模型建立的方法、原則,給出了用Matlab對其實現(xiàn)仿真的程序和仿真結(jié)果。 本文首次對胃的電機械活動建立量化模型,并首次成功地實現(xiàn)了用Matlab對胃電機械活動的三維動態(tài)模擬。在所建立的三維胃模型基礎(chǔ)上,根據(jù)實際胃生理,我們建立了胃電活動和蠕動收縮之間的量化關(guān)系模型,再由電機械耦合傳導(dǎo)規(guī)律,進一步建立了胃電機械活動傳導(dǎo)模型。最后用Matlab分別對靜息胃的電活動傳播和蠕動收縮胃的電機械活動的傳播進行三維動態(tài)模擬,給出了相應(yīng)的模擬結(jié)果。通過胃電機械活動的三維建模和三維動態(tài)模擬,形象地展現(xiàn)了胃電活動傳播和胃蠕動收縮過程,為胃的電機械活動提供了三維動態(tài)模擬方法和新的認知途徑。 總之,我們的研究工作不僅增進了對胃電生理和胃動力的理解,而且通過對胃電機械活動三維建模和動態(tài)模擬,形象展現(xiàn)了胃電活動傳播、胃蠕動收縮波的傳播過程,形象地揭示了胃電活動與胃動力之間的關(guān)系。特別是為胃電活動與胃動力的研究和模擬提供新的研究和認識途徑,使其在胃動力疾病研究和診斷中發(fā)揮更大的作用。
[Abstract]:The electromechanical activity of the stomach is the basis of its normal physiological function. There have been many results in the research, modeling and simulation of electromechanical activities of stomach for many years. However, we have not seen any reports on the model of electromechanical activity propagation and its three-dimensional dynamic simulation. The main work of this paper is to analyze the model of gastric electrical activity, to establish a three-dimensional model of gastric electrical conduction and peristaltic contraction, and then to simulate it dynamically. On the basis of expounding the generation, characteristics and functions of electromechanical activities of stomach, this paper first analyzes and simulates the electric activity model of ion mechanism with Matlab, and summarizes the laws and characteristics of different types of cell electrical activity. Then the conduction model of electromechanical activity is studied and simulated. Finally, the relationship and propagation model of electromechanical activity of stomach are established, and the three-dimensional dynamic simulation of electromechanical activity of stomach with Matlab is successfully realized. In this paper, the establishment and Matlab simulation of three-dimensional gastric model and coupled transmission model of electromechanical activity are discussed. In this paper, the mathematical analysis of H-H model and FHN model of traditional ion mechanism is carried out with Matlab, and the law of electrical activity is shown by image. Through comparison and analysis, the electric activity of H-H model and FHN model of traditional ion mechanism are compared and analyzed. Different patterns and characteristics of electrical activity between ICC cells and smooth muscle cells were summarized. The simulation results not only enhance our understanding of the function of ICC cells and smooth muscle cells, but also prove the rationality of these models. In this paper, the conical model and the column conductor model of gastric electrical conduction are studied, and the law of electrical conduction is analyzed. In this paper, a new serosal slow wave conduction model is established by using the methods and principles of these models, and the simulation is carried out with Matlab. The simulation results reflect the law of gastric electrical activity propagation and verify the reliability of the conduction model. In this paper, a three-dimensional gastric model is established and simulated by Matlab for the first time. In order to realize the three-dimensional gastric model as close as possible to the real gastric shape, we use several deformable cones (or columns) to approximate the static gastric shape, and establish a three-dimensional model of the static stomach. In this paper, the method and principle of establishing 3D gastric model are described in detail, and the program and result of simulation with Matlab are given. In this paper, a quantitative model of electromechanical activity of the stomach is established for the first time, and the three-dimensional dynamic simulation of the electromechanical activity of the stomach with Matlab is successfully realized for the first time. On the basis of the three-dimensional gastric model and the actual gastric physiology, we established a quantitative model of the relationship between gastric electrical activity and peristaltic contraction, and then further established the electromechanical conduction model of gastric electromechanical activity by electromechanical coupling conduction law. Finally, the electrokinetic propagation of resting stomach and the propagation of electromechanical activity of peristaltic contraction stomach were simulated by Matlab, respectively, and the corresponding simulation results were given. Through three-dimensional modeling and three-dimensional dynamic simulation of gastric electromechanical activity, the process of gastric electrical activity propagation and gastric peristalsis contraction is vividly demonstrated, which provides a three-dimensional dynamic simulation method and a new cognitive approach for gastric electromechanical activity. In a word, our research not only improves the understanding of gastric electrophysiology and gastric motility, but also shows the propagation process of gastric electrical activity and gastric peristaltic contraction wave by three-dimensional modeling and dynamic simulation of gastric electromechanical activity. The relationship between gastric electrical activity and gastric motility was vividly revealed. Especially, it provides a new research and understanding way for the study and simulation of gastric electrical activity and gastric motility, and makes it play a more important role in the study and diagnosis of gastric motility diseases.
【學(xué)位授予單位】：揚州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R35

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