本文選題：血管新生方式　切入點：出芽式血管新生　出處：《蘇州大學》2009年碩士論文　論文類型：學位論文

【摘要】： 毛細血管新生的主要方式為出芽和套疊,它們出現于不同的生理(機體生長過程)或病理(腫瘤和創(chuàng)傷修復等)條件下。近年來的文獻表明目前對血管新生方式的研究主要集中在現象的觀察描述和數學模擬,以及分子水平上闡述套疊和出芽過程中各種因子的作用。對于何種情況下采用出芽式血管新生,何種情況下采用套疊式還沒有明確的認識。本研究以探討組織缺氧程度對血管新生方式的影響為目標。通過大鼠解剖實驗觀察機體生長過程毛細血管新生的主要方式;通過模型構建從理論上分析比較機體生長過程、腫瘤生長和創(chuàng)傷修復過程中組織的缺氧程度;結合各種生理和病理情況下血管新生的方式進行討論。研究的主要內容包括以下兩部分。 第一部分主要是通過實驗觀察研究機體發(fā)育過程中組織緩慢缺氧情況下(機體生長)毛細血管新生的主要方式。根據套疊和出芽發(fā)生時毛細血管的形態(tài),判定大鼠長伸肌生長過程血管新生的主要方式;結合組織的缺氧程度,探討血管新生和組織缺氧程度的關系。結果得知,大鼠長伸肌生長過程血管新生的主要方式為套疊,因機體生長過程是緩慢的缺氧進程,所以推定緩慢缺氧情況下,血管新生的主要方式為套疊。 第二部分主要通過構建生長及血管形成模式從理論上探討不同缺氧程度下血管新生的主要方式,分析比較機體生長過程、腫瘤生長和創(chuàng)傷修復過程中組織的缺氧程度,闡明啟用不同種血管新生方式的形成機制。結果得知,機體生長過程組織的缺氧程度較小,為緩慢缺氧,血管新生的主要方式為套疊,所以緩慢缺氧情況下血管新生的主要方式為套疊;腫瘤生長過程組織的缺氧程度次之,為中度缺氧,前期血管新生的主要方式為出芽,后期即緩和生長期出現套疊式血管新生,所以中度缺氧情況下兩種方式共存;創(chuàng)傷修復過程中,組織的缺氧程度為急性,此條件下血管新生的主要方式為出芽。 毛細血管新生方式與組織缺氧程度的關系探知有助于進一步了解血管新生方式的機制,探討毛細血管網絡,設計有利于血管生長的生物醫(yī)用材料;有助于治療由血管新生引發(fā)的疾病。相信我們的研究對更進一步認識由血管新生引發(fā)的生理、病理情況有重要的理論及臨床上的參考作用。
[Abstract]:The main ways of capillary regeneration are sprouting and overlaying. They occur in different physiological (body growth processes) or pathological (tumor and wound repair) conditions. Recent studies have shown that recent studies of angiogenesis have focused on the observation, description and mathematical simulation of phenomena. And at the molecular level, explain the role of various factors in the process of overlay and budding. When to use budding angiogenesis, The purpose of this study was to explore the effect of tissue hypoxia on angiogenesis, and to observe the main ways of capillary neovascularization in the process of organism growth through rat anatomical experiments. The degree of hypoxia in the process of body growth, tumor growth and wound repair was analyzed and compared theoretically by model building. The main contents of this study are as follows: (1) Angiogenesis under various physiological and pathological conditions. The first part is to observe and study the main ways of capillary neovascularization in the slow anoxia of tissues during the development of the body, according to the morphology of capillaries at the time of intussusception and budding. The relationship between angiogenesis and tissue anoxia was studied. The results showed that the main pattern of angiogenesis during the growth of extensor longus in rats was intussusception. Because the growth of the body is a slow anoxic process, it is assumed that the main way of angiogenesis in slow hypoxia is intussusception. The second part mainly discusses the main ways of angiogenesis under different degrees of hypoxia by constructing growth and angiogenesis models, and analyzes and compares the degree of hypoxia in the process of body growth, tumor growth and wound repair. The results showed that the degree of hypoxia in the tissue was relatively small, which was slow anoxia, and the main way of angiogenesis was overlay. So the main way of angiogenesis under slow anoxia is intussusception; the degree of anoxia in tumor growth process is secondary to moderate hypoxia, and the main way of angiogenesis in the early stage is budding, that is, in the later stage of palliative growth, the overlapping angiogenesis occurs. In the process of wound repair, the degree of tissue hypoxia is acute, and the main way of angiogenesis under this condition is sprouting. The relationship between capillary neovascularization and tissue hypoxia is helpful to further understand the mechanism of angiogenesis, explore capillary network, and design biomedical materials conducive to vascular growth. It is believed that our research has important theoretical and clinical reference value for further understanding the physiological and pathological conditions caused by angiogenesis.
【學位授予單位】：蘇州大學
【學位級別】：碩士
【學位授予年份】：2009
【分類號】：R363

【引證文獻】

相關博士學位論文 前1條

1 孫自玲;多孔絲素蛋白膜材料的血管化進程研究[D];蘇州大學;2010年

相關碩士學位論文 前1條

1 胡綺;多孔絲素膜材料中血管新生模式機制的探索[D];蘇州大學;2012年

，

本文編號：1585574