本文關(guān)鍵詞：低頻交流磁誘導(dǎo)對(duì)記憶作用機(jī)理的研究　出處：《天津大學(xué)》2009年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 磁誘導(dǎo) 學(xué)習(xí)記憶 動(dòng)物實(shí)驗(yàn)

【摘要】： 利用外界物理因子影響腦內(nèi)變化進(jìn)而調(diào)節(jié)人的精神活動(dòng),一直是世界醫(yī)學(xué)領(lǐng)域中一項(xiàng)引人注目的研究活動(dòng)。目前,經(jīng)顱磁刺激技術(shù)已經(jīng)越來(lái)越多的用于學(xué)習(xí)與記憶功能的研究中,許多研究表明,不同形式的磁刺激可以促進(jìn)或者破壞學(xué)習(xí)記憶功能。這些結(jié)果顯示經(jīng)顱磁刺激技術(shù)已經(jīng)成為腦認(rèn)知研究的有效工具,并將更加廣泛的應(yīng)用于學(xué)習(xí)記憶的研究中。 在深入研究經(jīng)顱磁刺激對(duì)于學(xué)習(xí)記憶的影響機(jī)制后,設(shè)計(jì)實(shí)現(xiàn)了一套經(jīng)顱磁誘導(dǎo)系統(tǒng)。以環(huán)形單線圈作為磁場(chǎng)耦合線圈,利用經(jīng)典的ADuC845控制輸出不同頻率的正弦信號(hào),信號(hào)通過(guò)TDA7294功率放大電路,驅(qū)動(dòng)線圈產(chǎn)生磁場(chǎng)。該系統(tǒng)可產(chǎn)生不同頻率的正弦信號(hào),輸出時(shí)間可控。本設(shè)計(jì)以正弦形式(或類正弦)周期性變化的磁場(chǎng)取代脈沖磁場(chǎng)刺激和電刺激,作用于動(dòng)物腦部,觀察周期性變化的磁場(chǎng)對(duì)動(dòng)物學(xué)習(xí)記憶能力的影響。這種研究連續(xù)周期性變化磁場(chǎng)對(duì)大腦的影響異于以往所研究的脈沖磁場(chǎng),也不同于靜態(tài)恒定磁場(chǎng),將是對(duì)磁場(chǎng)與神經(jīng)相互作用新的探索。該經(jīng)顱磁誘導(dǎo)系統(tǒng)功能化設(shè)計(jì)使操作簡(jiǎn)單方便。 通過(guò)動(dòng)物學(xué)習(xí)記憶的行為學(xué)訓(xùn)練和測(cè)試,表明系統(tǒng)對(duì)記憶的增加是有所幫助的。同時(shí),為了更好的證明經(jīng)顱磁誘導(dǎo)的影響,本文還對(duì)提取誘導(dǎo)前后的大鼠腦電進(jìn)行功率譜分析,得出磁誘導(dǎo)能夠改變腦電功率譜分布的結(jié)論。這些實(shí)驗(yàn)結(jié)果不僅驗(yàn)證了理論的合理性和可行性,也為磁誘導(dǎo)開(kāi)辟了新的應(yīng)用領(lǐng)域,為提高記憶提供了新的途徑。
[Abstract]:The use of external physical factors to influence brain changes and thus regulate mental activities has been a noticeable research activity in the field of medicine in the world. At present. Transcranial magnetic stimulation (TMS) technology has been increasingly used in the study of learning and memory, many studies show that. Different forms of magnetic stimulation can promote or damage learning and memory function. These results show that transcranial magnetic stimulation has become an effective tool in brain cognitive research. And will be more widely used in the study of learning and memory. After deeply studying the influence mechanism of transcranial magnetic stimulation on learning and memory, a transcranial magnetic induction system is designed and implemented. The loop single coil is used as the coupling coil of magnetic field. The classical ADuC845 is used to control and output sinusoidal signals with different frequencies. The signal is driven by TDA7294 power amplifier circuit to produce magnetic field. This system can produce sinusoidal signals with different frequencies. The output time is controlled. This design uses sinusoidal (or sinusoid) periodic magnetic field instead of pulsed magnetic field stimulation and electrical stimulation to act on the animal brain. To observe the effect of periodically changing magnetic field on the learning and memory ability of animals, the effect of continuous periodic magnetic field on brain is different from that of pulse magnetic field and static constant magnetic field. It will be a new exploration of the interaction between magnetic field and nerve. The functional design of transcranial magnetic induction system makes the operation simple and convenient. The behavioral training and testing of animal learning and memory showed that the system was helpful to increase memory. At the same time, in order to better demonstrate the effect of transcranial magnetic induction. The results show that magnetic induction can change the distribution of EEG power spectrum. These experimental results not only verify the rationality and feasibility of the theory. It also opens up a new application field for magnetic induction and provides a new way to improve memory.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2009
【分類號(hào)】：R312

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 曹艷麗;磁刺激穴位對(duì)循經(jīng)溫場(chǎng)影響的研究[D];天津大學(xué);2010年

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本文編號(hào)：1373172