【摘要】：目的:偏頭痛是可以直接導致腦梗死的慢性神經血管性疾病,且發(fā)病機制尚不十分清楚,而近年來大量的研究表明偏頭痛與缺血性腦卒中患病風險的增高顯著相關,但具體關聯機制目前尚不明確。此次試驗通過觀察卒中風險評價指標hs-CRP和卒中危險因子HCY在偏頭痛患者血循環(huán)內含量的變化,從新的角度探討偏頭痛的發(fā)病機制,從而提供新的防治策略。方法:偏頭痛組選自2016年10月至2017年01月在山西省人民醫(yī)院就診的偏頭痛患者24例,均為無先兆偏頭痛患者,其中偏頭痛發(fā)作期患者10例,偏頭痛緩解期患者14例;健康對照組選自于本院體檢中心以及健康志愿者,共23例。偏頭痛組及對照組均空腹8h后于清晨抽取血液樣本,標本經抗凝,離心,取上層血清分析。采用散射比濁法測定血hs-CRP的含量,采用速率法測定血HCY的含量。采用SPSS16.0軟件進行數據統(tǒng)計分析。結果:1.血清hs-CRP的含量(mg/L)(結果采用Me±QR描述):偏頭痛發(fā)作期患者(10例)3.65±1.14,緩解期患者(14例)2.21±0.81,對照組(23例)0.77±0.33,發(fā)作期及緩解期患者均與對照組比較,均P0.05;發(fā)作期與緩解期比較,P0.05;2.血清HCY含量(umol/L)(結果采用Me±QR描述):偏頭痛組(24例)20.53±2.90,對照組(23例)11.89±3.31,偏頭痛組與對照作比較,P0.05。結論:1.偏頭痛緩解期患者血清hs-CRP較對照組升高,提示偏頭痛患者在緩解期也存在炎癥狀態(tài);發(fā)作期患者血清hs-CRP較緩解期進一步升高,支持偏頭痛發(fā)作期伴隨炎性因子的釋放;2.偏頭痛組患者血HCY高于對照組,提示HCY的升高可能參與偏頭痛的發(fā)病機制;3.偏頭痛患者血清hs-CRP及HCY高于對照組,推測二者可能系偏頭痛與缺血性腦卒中潛在的關聯機制之一。
[Abstract]:Objective: migraine is a chronic neurovascular disease that can directly lead to cerebral infarction, and the pathogenesis of migraine is not very clear. In recent years, a large number of studies have shown that migraine is significantly related to the increased risk of ischemic stroke. However, the specific linkage mechanism is not clear at present. By observing the changes of stroke risk assessment index hs-CRP and stroke risk factor HCY in blood circulation of migraine patients, this study explored the pathogenesis of migraine from a new point of view, so as to provide new strategies for prevention and treatment of migraine. Methods: from October 2016 to January 2017, 24 migraine patients in Shanxi Provincial people's Hospital were enrolled in the migraine group. All patients were migraine patients without premonitory symptoms, including 10 migraine patients in attack period and 14 migraine patients in remission period. The healthy control group was selected from the physical examination center of our hospital and healthy volunteers, a total of 23 cases. The blood samples were taken in the morning after 8 hours fasting in both the migraine group and the control group. The samples were analyzed by anticoagulation centrifugation and upper layer serum analysis. The content of hs-CRP in blood was determined by nephelometry and the content of HCY in blood was determined by rate method. The data were analyzed by SPSS16.0 software. Results: 1. Serum hs-CRP content (mg/L) (results described by Me 鹵QR): migraine attack (10 cases) (3.65 鹵1.14), remission (14 cases) 2.21 鹵0.81, control group (23 cases) 0.77 鹵0.33, The patients in paroxysmal stage and remission stage were compared with the control group (P 0.05). Compared with the remission stage, P0.05m2. Serum HCY content (umol/L) (results described by Me 鹵QR): 20.53 鹵2.90,11.89 鹵3.31in the control group (n = 23) and 20.53 鹵2.90in the control group (n = 24). Compared with the control group, the patients with migraine pain were compared with the control group (P 0.05). Conclusions: 1. The levels of serum hs-CRP in migraine patients in remission stage were higher than those in control group, suggesting that migraine patients also had inflammatory state in remission stage, and serum hs-CRP in patients with paroxysmal migraine was further higher than that in remission stage, which supported the release of inflammatory factors in migraine paroxysmal phase. 2. The level of serum HCY in migraine group was higher than that in control group, suggesting that the increase of HCY might be involved in the pathogenesis of migraine. The levels of serum hs-CRP and HCY in migraine patients were higher than those in control group, which suggested that they might be one of the potential mechanisms of migraine and ischemic stroke.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R747.2

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