【摘要】：目的：通過(guò)收集本科19例確診為淋巴瘤病人的資料,提高對(duì)原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤的診斷準(zhǔn)確率,改善治療方法,延長(zhǎng)患者預(yù)后生存周期。方法：回顧性分析自2011年9月至2013年6月在我科行手術(shù)治療,術(shù)后病理確診為原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤的病人,通過(guò)對(duì)原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤的影像學(xué)特點(diǎn)、腦脊液檢測(cè)、脊髓學(xué)檢測(cè)及病理學(xué)特點(diǎn)進(jìn)行分析,以求提高原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤的診斷。通過(guò)19例患者除4例失訪(fǎng)患者外,剩余15例隨訪(fǎng)患者在經(jīng)過(guò)3-27個(gè)月的隨訪(fǎng)期后,對(duì)患者的生存率、生存者中有生活自理能力患者人數(shù)、腫瘤復(fù)發(fā)率、腫瘤復(fù)發(fā)后死亡率、腫瘤的病理分型等數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析,分析出影響原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤的治療及預(yù)后因素。結(jié)果：19例患者中4例患者失訪(fǎng),剩余15例隨訪(fǎng)病人,6例患者截止隨訪(fǎng)期存活,9例患者死亡。6例患者中僅1例有生活自理能力。同時(shí),15例患者中,7例患者腫瘤復(fù)發(fā),7例腫瘤復(fù)發(fā)患者中5例患者死亡。19例病人中17例病人的病理類(lèi)型為彌漫大B細(xì)胞淋巴瘤。結(jié)論：原發(fā)性中樞神經(jīng)系統(tǒng)淋巴瘤術(shù)前明確診斷困難,治療棘手,術(shù)后并發(fā)癥多,術(shù)后死亡率高,術(shù)后放療聯(lián)合化療可提高患者的生存周期及改善生活質(zhì)量。
[Abstract]:Aim: to improve the accuracy of diagnosis of primary central nervous system lymphoma (CNS) by collecting the data of 19 cases diagnosed as lymphoma, and to improve the treatment method and prolong the life cycle of prognosis. Methods: from September 2011 to June 2013, we retrospectively analyzed the imaging features of primary central nervous system lymphoma in patients with primary central nervous system lymphoma, who underwent surgical treatment from September 2011 to June 2013, and who were pathologically diagnosed as primary central nervous system lymphoma after operation. Cerebrospinal fluid examination, spinal cord examination and pathological characteristics were analyzed in order to improve the diagnosis of primary central nervous system lymphoma. After a follow-up period of 3 months and 27 months, the survival rate of the patients, the number of patients with the ability to take care of themselves, the recurrence rate of the tumor, and the mortality rate after the recurrence of the tumor were studied in 19 patients, except 4 missing patients, and the remaining 15 patients were followed up for 3 months and 27 months after the follow-up period. The factors affecting the treatment and prognosis of primary central nervous system lymphoma (PNS) were analyzed by statistical analysis of the pathological types of tumors. Results: of the 19 patients, 4 patients lost follow-up, the remaining 15 patients were followed-up, 6 patients survived until the follow-up period, 9 patients died, and only one of the 6 patients had the ability to take care of themselves. At the same time, of the 15 patients, 7 had tumor recurrence, 5 had died of tumor recurrence, and 17 of 19 patients had diffuse large B-cell lymphoma. Conclusion: preoperative diagnosis of primary central nervous system lymphomas is difficult and difficult to treat. There are many complications and high mortality after operation. Postoperative radiotherapy combined with chemotherapy can improve the life cycle and quality of life of the patients.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R739.4

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