【摘要】：目的探討急性腦梗死患者血清膽堿酯酶活性與腦梗死的相關(guān)性。 方法選取在我院住院的201例急性腦梗死患者,將腦梗死組分為非大面積腦梗死組、大面積腦梗死組兩組,其中非大面積腦梗死組190例,大面積腦梗死組11例。選取體檢中心健康人37例為正常對照組。對腦梗死組與正常對照組的血清膽堿酯酶及血脂、血糖進行檢測。并采用統(tǒng)計學軟件對實驗結(jié)果進行統(tǒng)計學意義的分析。 結(jié)果非大面積腦梗死組膽堿酯酶活性為(11083.33±1968.28)U/L,大面積腦梗死組膽堿酯酶活性為(6844.16±2270.41)U/L,對照組膽堿酯酶活性為(9570.59±1641.25)U/L,非大面積腦梗死組膽堿酯酶較對照組升高(P=0.000),大面積梗死組膽堿酯酶較對照組降低(P=0.003)。根據(jù)多元線性回歸分析,血清膽堿酯酶與血糖,總膽固醇,甘油三酯呈顯著正相關(guān)(P0.05)。Logistic回歸分析提示,血清CHE活性與腦梗死發(fā)病密切相關(guān)(95%可信區(qū)間,P=0.000)。 結(jié)論血清CHE活性是血糖,甘油三酯,總膽固醇的影響因素,呈正相關(guān)。血清膽堿酯酶活性升高與腦梗死的發(fā)生相關(guān),大面積腦梗死患者血清膽堿酯酶活性降低,與病情嚴重程度相關(guān)。
[Abstract]:Objective to investigate the correlation between serum cholinesterase activity and cerebral infarction in patients with acute cerebral infarction. Methods 201 patients with acute cerebral infarction in our hospital were divided into two groups: non-large area cerebral infarction group, and large area cerebral infarction group, including 190 cases of non-large area cerebral infarction group and 11 cases of large area cerebral infarction group. Thirty-seven healthy persons in physical examination center were selected as normal control group. Serum cholinesterase, blood lipid and blood glucose were measured in cerebral infarction group and normal control group. Statistical software was used to analyze the statistical significance of the experimental results. Results the cholinesterase activity was (11083.33 鹵1968.28) U / L in the non-large area cerebral infarction group, (6844.16 鹵2270.41) U / L in the large area cerebral infarction group and (9570.59 鹵1641.25) U / L in the control group. The cholinesterase in non-large area cerebral infarction group was higher than that in control group (P < 0. 000), and the cholinesterase in large area infarction group was lower than that in control group (P < 0. 003). According to multiple linear regression analysis, serum cholinesterase was positively correlated with blood glucose, total cholesterol and triglyceride (P0.05). Logistic regression analysis showed that serum CHE activity was closely related to the incidence of cerebral infarction (95% confidence interval). (P _ 0.000). Conclusion Serum CHE activity is positively correlated with blood glucose, triglyceride and total cholesterol. The increase of serum cholinesterase activity was related to the occurrence of cerebral infarction and the decrease of serum cholinesterase activity in patients with large area cerebral infarction, which was related to the severity of the disease.
【學位授予單位】：青島大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R743.3

【參考文獻】

相關(guān)期刊論文 前10條

1 李艷萍;黃萍;胡秀芬;王宏偉;;神經(jīng)系統(tǒng)和免疫系統(tǒng)的聯(lián)系——膽堿抗炎通路[J];國際兒科學雜志;2006年05期

2 黃帆;楊靜;仲飛;徐雪;馬中富;;大面積腦梗死患者早期血清膽堿酯酶活性檢測的臨床意義[J];熱帶醫(yī)學雜志;2008年10期

3 鄭捷,周志俊;上海市正常人群血清丁酰膽堿酯酶基因多態(tài)性研究[J];中國工業(yè)醫(yī)學雜志;2003年06期

4 何善述,鄧耀祖,馮宗忱,龔成新,余英宏;血清膽堿酯酶與血脂的關(guān)系[J];生物化學雜志;1992年02期

5 劉秀娟;劉伯仁;張謙;龍永錦;;多器官功能障礙綜合征血清白蛋白及膽堿酯酶水平的意義和預后的關(guān)系[J];陜西醫(yī)學雜志;2008年07期

6 倪藍;盧銀紅;;早期多發(fā)傷患者血清膽堿酯酶檢測的意義[J];實用醫(yī)技雜志;2007年29期

7 王開富,陸付耳,徐麗君,冷三華,黃光英;膽堿酯酶抑制劑對化學性糖尿病影響的實驗研究[J];中國病理生理雜志;2004年09期

8 饒明俐;;《中國腦血管病防治指南》摘要(三)[J];中風與神經(jīng)疾病雜志;2006年01期

9 李淮安;王景梅;;血清膽堿酯酶變化與病危程度及愈后預測價值[J];中國療養(yǎng)醫(yī)學;2008年09期

10 曹衛(wèi)紅;柴家科;孫天駿;沈小鵬;楊紅明;賈曉明;盛志勇;;血清膽堿酯酶在大面積燒傷患者營養(yǎng)狀態(tài)評價中的意義[J];中國臨床營養(yǎng)雜志;2006年01期

，

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