【摘要】：[目的]探討偏側(cè)面肌痙攣(hemifacial spasm,HFS)患者的情感、睡眠和認(rèn)知障礙的發(fā)生情況,為制定相應(yīng)的臨床治療措施提供依據(jù),以提高患者的生活質(zhì)量。[方法]收集2015年1月至2017年2月在昆明醫(yī)科大學(xué)第一附屬醫(yī)院神經(jīng)內(nèi)科門診就診的偏側(cè)面肌痙攣患者30例,同時(shí)納入年齡、性別和文化程度與患者相匹配的30名健康對(duì)照,采用14項(xiàng)版漢密爾頓焦慮量表(Hamilton Anxiety Scale,HAMA)、17 項(xiàng)版漢密爾頓抑郁量表(Hamilton Depression Scale,HAMD)、匹茲堡睡眠質(zhì)量指數(shù)量表(Pittsburgh Sleep Quality Index,PSQI)和安登布魯克認(rèn)知功能檢查(ADDENBROOKE'S Cognitive Function Test,ACE-Ⅲ)對(duì)兩組受試者進(jìn)行測(cè)評(píng),將所獲數(shù)據(jù)錄入SPSS 21.0軟件進(jìn)行對(duì)比分析。[結(jié)果](1)焦慮評(píng)估顯示,患者焦慮的發(fā)生率[14例(46.7%)]較健康對(duì)照組[5例(16.7%)]高,差異有統(tǒng)計(jì)學(xué)意義(X2=6.239,P=0.012);焦慮的發(fā)生與痙攣程度無(wú)關(guān),差異無(wú)統(tǒng)計(jì)學(xué)意義(X2=3.106,P = 0.795);女性患者發(fā)生焦慮的比例[12/20例(60.0%)]高于男性患者[2/10例(20.0%)],但差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.058);病程≥10年的患者發(fā)生焦慮的比例[5/5例(100.0%)]明顯高于病程10年的患者[9/25例(36.0%)],差異有統(tǒng)計(jì)學(xué)意義(P=0.014);(2)抑郁評(píng)估顯示,患者抑郁的發(fā)生率[12例(40%)]較健康對(duì)照組[4例(13.3%)]高,差異有統(tǒng)計(jì)學(xué)意義(x2=5.455,P=0.020);抑郁的發(fā)生與痙攣程度無(wú)關(guān),差異無(wú)統(tǒng)計(jì)學(xué)意義(x2=4.098,P= 0.663);女性患者發(fā)生抑郁的比例[11/20例(55.5%)]明顯高于男性[1/10例(10.0%)],差異有統(tǒng)計(jì)學(xué)意義(P=0.024);病程≥10年的患者發(fā)生抑郁的比例[5/5例(100.0%)]明顯高于病程10年的患者[7/25例(28.0%)],差異有統(tǒng)計(jì)學(xué)意義(P=0.006);(3)睡眠評(píng)估顯示,患者組與對(duì)照組受試者的PSQI主觀睡眠質(zhì)量[(2.00±1.00)分與(1.00±1.25)分,z=-2.700,P=0.007]、睡眠潛伏期[(2.00±1.00)分與(1.00±1.00),z=-3.485,P=0.000]、睡眠持續(xù)性[(1.00±2.00)分與(0.00±1.00)分,z=-2.263,P=0.024]、白天功能紊亂[(1.00±1.25)分與(1.00±1.00)分,z=-2.350,P=0.019]和 PSQI 總分[(7.47±4.78)分與(4.23±3.23)分,t=-3.070,P=0.003]差異有統(tǒng)計(jì)學(xué)意義(均P0.05);習(xí)慣性睡眠效率[(1.00±2.00)分與(0.00±1.00)分,z=-1.626,P=0.104]、睡眠紊亂[(1.00±0.25)分與(1.00±1.00)分,z=-1.040,P=0.299]、使用睡眠藥物[(0.00±0.00)分與(0.00±0.00)分,z=-1.043,P=0.297]差異無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05);(4)認(rèn)知評(píng)估顯示,患者組與對(duì)照組受試者的注意力[(17.00±2.25)分與(17.00±2.00),z=-0.241,P=0.810]、記憶力[(19.57±4.6 分與(18.43±4.24),t=-0.992,P=0.325]、語(yǔ)言流利性[(9.53±2.49)分與(10.37±2.27)分,t=1.356,P=0.180]、語(yǔ)言[(18.63±2.55)分與(19.87±2.37)分,t=1.938,P=0.058]、視空間[(13.27±3.11)分與(14.23±1.87)分,t=1.460,P=0.150]和 ACEⅢ總分[(77.60±11.47)分與(79.30±7.37)分,t=0.683,P=0.497]差異無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05)。[結(jié)論]本研究結(jié)果初步表明,偏側(cè)面肌痙攣患者存在焦慮、抑郁情緒和睡眠障礙,而認(rèn)知功能無(wú)明顯異常。研究結(jié)果仍需要進(jìn)一步大樣本數(shù)據(jù)驗(yàn)證。
[Abstract]:[objective] to investigate the occurrence of affective, sleep and cognitive disorders in patients with hemifacial spasm (hemifacial spasm,HFS), and to provide evidence for clinical treatment to improve the quality of life of patients with hemifacial spasm (hemifacial spasm,HFS). [methods] A total of 30 patients with hemifacial spasm from January 2015 to February 2017 in Department of Neurology, first affiliated Hospital of Kunming Medical University were enrolled in the study. 14 items of Hamilton anxiety scale (Hamilton Anxiety Scale,HAMA), 17 items of Hamilton Depression scale (Hamilton Depression Scale,HAMD) and Pittsburgh Sleep quality Index (Pittsburgh Sleep Quality Index,) were used. PSQI) and Adenbrook Cognitive function Test (ADDENBROOKE'S Cognitive Function Test,ACE- 鈪，

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