【摘要】：目的:通過檢測帕金森(Parkinson's disease,PD)及血管性帕金森綜合征(Vascular parkinsonism,VP)患者外周血清白介素6及白介素32水平,進一步了解炎癥因子與患者臨床癥狀的相關(guān)性。方法:采用橫斷面研究,選取2014年10月至2016年10月之間我院門診及住院部PD患者64例及VP患者48例,對入組患者進行量表評分(UPDRSIII統(tǒng)一帕金森評分量表評分、Hoehn-Yahr分級量表、NMSS帕金森非運動障礙評價量表及MMSE簡易智能精神狀態(tài)檢查量表)。同時收集河南科技大學健康體檢中心中老年體檢者60例。采用ELISA法檢測患者及健康體檢者外周血清中白介素6及白介素32水平。采用SPSS 21.0軟件對對比分析帕金森與血管性帕金森綜合征患者兩種炎癥因子與各量表評分的相關(guān)性,P0.05有統(tǒng)計學意義。結(jié)果:1.VP患者的發(fā)病年齡大于PD患者的發(fā)病年齡(F=32.452,P=0.000);VP患者左旋多巴用量高于PD患者(t=2.792,P=0.006);與PD患者相比,VP患者更易出現(xiàn)智能損害(t=2.920,P=0.004);2.PD患者血清白介素6水平顯著高于VP患者(P=0.005),且兩組患者血清白介素6水平顯著高于對照組(P=0.000);VP患者血清白介素32水平顯著高于PD患者,且均顯著高于對照組(P=0.000);3.PD患者的病程與運動癥狀評分及左旋多巴用量呈正相關(guān);4.VP患者病程與患者運動等級及智能狀態(tài)成正相關(guān);5.白介素32水平與PD患者NMSS評分存在正相關(guān)關(guān)系(r=0.690,P=0.000);6.白介素32水平與VP患者UPDRSIII評分(r=0.511,P=0.000)及Hoehn-Yahr評分(r=0.602,P=0.000)呈正相關(guān)。結(jié)論:1.兩組患者白介素6及白介素32均顯著高于對照組;2.白介素6與PD患者及VP患者的臨床癥狀均無關(guān),白介素32與PD患者的非運動癥狀及VP患者的運動癥狀均有顯著正相關(guān)。
[Abstract]:Aim: to investigate the relationship between inflammatory factors and clinical symptoms in patients with Parkinson's disease (Parkinson's disease,PD) and vascular Parkinson's syndrome (Vascular parkinsonism,VP) by detecting the levels of interleukin 6 and interleukin 32 in peripheral blood. Methods: from October 2014 to October 2016, 64 patients with PD and 48 patients with VP were selected by cross-sectional study. The patients were assessed with the UPDRSIII Unified Parkinson's scale (UPDRSIII), including the Hoehn-Yahr scale, the NMSS Parkinson's Non-motor Disorder scale and the MMSE's Mini-Mental State scale. At the same time, we collected 60 cases of middle and old people in the health examination center of Henan University of Science and Technology. The levels of interleukin 6 and interleukin 32 in peripheral serum of patients and healthy persons were detected by ELISA method. SPSS 21.0 software was used to compare and analyze the correlation between the two inflammatory factors and the scores of each scale in patients with Parkinson's syndrome and vascular Parkinson's syndrome (P 0.05). Results: 1. The onset age of VP patients was greater than that of PD patients (F = 32.452P 0.000). The dosage of levodopa in patients with VP was higher than that in patients with PD (t = 2.792 P0. 006). Compared with PD patients, patients with VP were more likely to suffer from intellectual impairment (tn 2.920 P0. 004). 2. The level of interleukin 6 in patients with PD was significantly higher than that in patients with VP. (2) the level of serum interleukin 6 in patients with PD was significantly higher than that in patients with VP. The level of serum interleukin 6 in the two groups was significantly higher than that in the control group (P < 0. 000). The serum level of interleukin 32 in the patients with VP was significantly higher than that in the patients with PD. The course of disease was significantly higher than that of the control group (P0. 000). 3. There was a positive correlation between the course of disease and the score of motor symptom and the dosage of levodopa. 4. There was a positive correlation between the course of disease and the motor grade and intelligence state of the patients with VP. There was a positive correlation between the level of IL 32 and the NMSS score of PD patients (r 0. 690 P 0. 000). The level of interleukin 32 was positively correlated with the UPDRSIII score (r = 0.511) and the Hoehn-Yahr score (r = 0.602) in patients with VP. Conclusion 1. The levels of IL 6 and IL 32 in the two groups were significantly higher than those in the control group. Interleukin-6 was not associated with the clinical symptoms of PD patients and VP patients. Interleukin-32 was positively correlated with non-motor symptoms in PD patients and sports symptoms in VP patients.
【學位授予單位】：河南科技大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R742.5

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