發(fā)布時間：2018-06-16 06:15

  本文選題：偏頭痛 + 遺傳�。� 參考：《中國神經(jīng)精神疾病雜志》2017年06期

【摘要】：目的觀察偏頭痛家族聚集性患者的臨床特征,分析其一級親屬的患病風(fēng)險因素。方法收集資料完整的偏頭痛患者72例,根據(jù)有無偏頭痛家族史分為兩組,有偏頭痛家族史組及無偏頭痛家族史組。利用問卷采集兩組患者臨床資料,單因素分析篩選出有統(tǒng)計學(xué)意義的變量后進(jìn)行多因素logistic回歸分析其一級親屬患病的危險因素。結(jié)果 72例中至少有1名一級親屬患有偏頭痛者37例,家族史陽性率為51.4%。與家族史陰性的偏頭痛先證者比較,家族史陽性的先證者在性別(P=0.675)、年齡(P=0.598)、病程(P=0.419)、先兆(P=0.669)、頭痛程度(P=0.837)、發(fā)作頻率(P=0.465)及頭痛伴隨癥狀、頭痛部位、頭痛性質(zhì)方面差異無統(tǒng)計學(xué)意義;與家族史陰性的頭痛先證者比較,家族史陽性的先證者在起病年齡早(16歲)方面的差異(48.6%vs.22.9%,χ~2=5.186,P=0.023)及在頭痛發(fā)作持續(xù)時間長(≥24 h)方面的差異(35.1%vs.14.3%,χ~2=4.170,P=0.041)有統(tǒng)計學(xué)意義(P0.05)。多因素回歸發(fā)現(xiàn),發(fā)病年齡早(OR=2.986,95%CI:1.621~5.503)、頭痛發(fā)作持續(xù)時間長(OR=2.320,95%CI:1.219~4.415)的先證者,其一級親屬患病風(fēng)險高(P0.05)。結(jié)論起病年齡早及頭痛持續(xù)時間長的偏頭痛患者,其一級親屬患偏頭痛的風(fēng)險更高。
[Abstract]:Objective to observe the clinical characteristics of migraine family cluster patients and analyze the risk factors of their first degree relatives. Methods 72 cases of migraine with complete data were divided into two groups according to the family history of migraine: the group with family history of migraine and the group without family history of migraine. The clinical data of two groups of patients were collected by questionnaire and the risk factors of first-degree relatives were selected by univariate analysis and multivariate logistic regression analysis. Results among 72 cases, at least one first-degree relative had migraine in 37 cases, and the positive rate of family history was 51.4. Compared with the migraine proband with negative family history, the patients with positive family history had no significant difference in sex (P < 0. 675), age (P = 0. 598), course of disease (P = 0. 419), omen (P = 0. 669), degree of headache (P = 0. 837), frequency of attack (P = 0. 465) and accompanied symptoms of headache, headache location and headache nature. Compared with those with negative family history, there were significant differences in the onset age of headache (48.6vs.22.9V) and the longer duration of headache (鈮，

本文編號：2025678