本文選題：非運(yùn)動(dòng)癥狀 + 單核細(xì)胞趨化蛋白-�。� 參考：《中風(fēng)與神經(jīng)疾病雜志》2017年04期

【摘要】：目的檢測(cè)帕金森病(PD)患者血清單核細(xì)胞趨化蛋白-1(MCP-1)、巨噬細(xì)胞炎性蛋白-1α(MIP-1α)水平,并探討其與PD、尤其與非運(yùn)動(dòng)癥狀(non-motor symptoms,NMS)的相關(guān)性。方法采用ELISA法對(duì)67例PD組患者及年齡、性別匹配的34例正常對(duì)照組血清MCP-1、MIP-1α水平進(jìn)行檢測(cè)。采用UPDRSⅢ評(píng)分和Hoehn-Yahr分級(jí)對(duì)PD患者運(yùn)動(dòng)功能進(jìn)行評(píng)估,將其分為早期、中晚期;用PD非運(yùn)動(dòng)癥狀評(píng)定量表(NMSQuest)對(duì)NMS損害程度進(jìn)行總體評(píng)估;用漢密爾頓抑郁量表(HAMD)、漢密爾頓焦慮量表(HAMA)、簡(jiǎn)易精神狀態(tài)評(píng)價(jià)量表(MMSE)對(duì)患者抑郁、焦慮、認(rèn)知功能評(píng)估,并用Pearson直線相關(guān)分析檢驗(yàn)MCP-1、MIP-1α濃度與各量表評(píng)分之間的相關(guān)性。結(jié)果 PD患者血清MCP-1、MIP-1α水平明顯高于健康對(duì)照組(P0.01);血清MCP-1、MIP-1α水平與抑郁、焦慮、認(rèn)知功能呈顯著正相關(guān),特別是發(fā)現(xiàn)PD早期患者血清MCP-1、MIP-1α水平與HAMD評(píng)分呈顯著正相關(guān),PD中晚期患者血清MCP-1、MIP-1α水平與MMSE評(píng)分呈負(fù)相關(guān);中晚期PD患者血清MCP-1、MIP-1α水平顯著高于PD早期,PD合并抑郁、認(rèn)知功能障礙組血清MCP-1、MIP-1α水平顯著高于PD未合并抑郁、認(rèn)知功能正常組(P均0.01)。結(jié)論血清MCP-1、MIP-1α可能參與PD的發(fā)病過(guò)程,在PD早期與抑郁顯著正相關(guān),在PD晚期與認(rèn)知功能障礙顯著正相關(guān)。PD患者血清MCP-1、MIP-1α水平隨著運(yùn)動(dòng)癥狀、非運(yùn)動(dòng)癥狀(如抑郁、認(rèn)知功能)的加重而升高。
[Abstract]:Objective to detect the levels of monocyte chemoattractant protein (MCP-1a) and macrophage inflammatory protein-1 偽 (MIP-1 偽) in patients with Parkinson's disease (PD), and to explore its correlation with PD-, especially non-motor symptoms (non-motor MMP). Methods the serum levels of MCP-1and MIP-1 偽 in 67 PD patients and 34 normal controls matched by age and sex were measured by ELISA. The motor function of PD patients was evaluated with UPDRS 鈪，

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