本文選題：腦腫瘤 + 膠質(zhì)瘤�。� 參考：《放射學(xué)實踐》2017年04期

【摘要】：目的:探討氨基質(zhì)子轉(zhuǎn)移(APT)MRI對腦膠質(zhì)瘤分級的診斷價值及其與腫瘤細(xì)胞增殖標(biāo)記物Ki-67表達(dá)水平的相關(guān)性。方法:經(jīng)病理證實的21例腦膠質(zhì)瘤患者術(shù)前行常規(guī)MR平掃、增強(qiáng)及APT掃描,其中低級別膠質(zhì)瘤8例(WHOⅠ~Ⅱ級),高級別膠質(zhì)瘤13例(WHOⅢ~Ⅳ級)。在腫瘤實質(zhì)區(qū)選取5~10個ROI,測量并計算MTRasym值。采用Mann-Whitney-Wilcoxon檢驗比較高低級別膠質(zhì)瘤間MTRasym值的差異,采用Spearman相關(guān)分析來分析MTR_(asym)值與腫瘤Ki-67表達(dá)水平的相關(guān)性。結(jié)果:高級別膠質(zhì)瘤的MTR_(asym)值(4.41%±2.23%)明顯高于低級別膠質(zhì)瘤(3.83%±2.02%),差異有統(tǒng)計學(xué)意義(W=5816,Z=-3.01,P0.05)。高級別膠質(zhì)瘤的Ki-67的表達(dá)水平(38.85%±21.03%)明顯高于低級別膠質(zhì)瘤(4.13%±2.64%),差異有統(tǒng)計學(xué)意義(W=2606,Z=-11.54,P0.05)。膠質(zhì)瘤的MTRasym值與Ki-67表達(dá)水平呈正相關(guān)(r=0.25,P0.001)。結(jié)論:MR氨基質(zhì)子轉(zhuǎn)移成像可用于鑒別高低級別膠質(zhì)瘤,對預(yù)測腫瘤細(xì)胞增殖有潛在價值。
[Abstract]:Objective: to investigate the diagnostic value of APTT MRI in glioma grading and its correlation with the expression of proliferative marker Ki-67. Methods: 21 cases of brain glioma confirmed by pathology were examined with conventional Mr scan before operation, including 8 cases of low grade gliomas and 13 cases of high grade gliomas with grade 鈪，

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