本文選題：腦小血管病　切入點(diǎn)：腎小球?yàn)V過(guò)率　出處：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年14期

【摘要】：目的 探討腦小血管病(CSVD)患者的腎小球?yàn)V過(guò)率(GFR)和尿微量白蛋白(m ALB)水平與認(rèn)知損害的關(guān)系。方法 選取84例CSVD患者(CSVD組)和50例健康體檢者(對(duì)照組)為研究對(duì)象,測(cè)定患者的生化指標(biāo)和m ALB,計(jì)算GFR,分析GFR和m ALB與認(rèn)知損害的相關(guān)性。結(jié)果 CSVD組的GFR、尿微量白蛋白陽(yáng)性率與對(duì)照組比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),CSVD組的GFR水平低于對(duì)照組,尿微量白蛋白水平則高于對(duì)照組;CSVD患者GFR陽(yáng)性組的Mo CA評(píng)分低于GFR陰性組,合并VCI發(fā)生率則高于GFR陰性組;CSVD患者尿微量白蛋白陽(yáng)性組的Mo CA評(píng)分低于尿微量白蛋白陰性組,合并VCI發(fā)生率則高于尿微量白蛋白陰性組。結(jié)論 CSVD合并GFR及m ALB水平異常的患者均存在不同程度認(rèn)知功能障礙,GFR及m ALB水平異�？赡軈⑴cCSVD認(rèn)知功能損害的發(fā)病過(guò)程,GFR和m ALB的檢測(cè)對(duì)于CSVD合并認(rèn)知功能損害的早期篩查具有重要意義。
[Abstract]:Objective to investigate the relationship between glomerular filtration rate (GFR) and urinary albumin (Alb) levels and cognitive impairment in patients with small cerebral vascular disease (CSVD). Methods 84 patients with CSVD and 50 healthy controls were selected as subjects. The correlation between GFR and m ALB and cognitive impairment was analyzed. Results compared with the control group, the positive rate of urinary microalbumin in the CSVD group was lower than that in the control group, and the GFR level in the CSVD group was lower than that in the control group. The level of urinary microalbumin was higher in GFR positive group than that in GFR negative group, and the incidence of VCI was higher in GFR negative group than that in GFR negative group. The incidence of VCI in patients with VCI was higher than that in patients with negative urinary microalbumin.Conclusion the abnormal levels of GFR and m ALB in patients with CSVD and abnormal GFR and m ALB levels may be involved in the development of cognitive impairment of CSVD. The detection of GFR and m ALB plays an important role in the early screening of CSVD with cognitive impairment.
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本文編號(hào)：1671867