本文選題：小膠質細胞　切入點：中樞神經(jīng)系統(tǒng)　出處：《醫(yī)學研究生學報》2017年02期 　論文類型：期刊論文

【摘要】：小膠質細胞廣泛分布于中樞神經(jīng)系統(tǒng),是神經(jīng)系統(tǒng)中發(fā)揮免疫功能的主要細胞,生理情況下起監(jiān)視作用,穩(wěn)定內環(huán)境,小膠質細胞對外界刺激非常敏感,一旦中樞神經(jīng)系統(tǒng)發(fā)生輕微病理變化即可激活小膠質細胞,活化后的小膠質細胞一方面發(fā)揮吞噬作用,吞噬細胞碎片,分泌生長因子促進神經(jīng)修復,另一方面也能分泌一些炎癥因子、谷氨酸、一氧化氮等,加重炎癥反應,引起繼發(fā)損傷。文中將對小膠質細胞的特性及其在中樞神經(jīng)系統(tǒng)疾病中的作用進行綜述,為中樞神經(jīng)系統(tǒng)疾病的治療提供新靶點。
[Abstract]:Microglia, which are widely distributed in the central nervous system, are the main cells in the nervous system that play an immune function. Under physiological conditions, microglia play a monitoring role and stabilize the internal environment. Microglia are very sensitive to external stimuli. Once slight pathological changes occur in the central nervous system, microglia can be activated. On the one hand, activated microglia play a role in phagocytosis, phagocytic fragments, and secretion of growth factor to promote nerve repair. On the other hand, it can also secrete some inflammatory factors, such as glutamate, nitric oxide and so on, which aggravate the inflammatory reaction and cause secondary injury. This paper reviews the characteristics of microglia and its role in central nervous system diseases. To provide a new target for the treatment of central nervous system diseases.
【作者單位】： 昆明醫(yī)科大學第二附屬醫(yī)院中心實驗室;昆明醫(yī)科大學第二附屬醫(yī)院科教處;
【基金】：云南省科技計劃項目-省應用基礎研究(昆醫(yī)聯(lián)合專項)(2013FB150,2015FA006) 云南省教育廳科學研究項目基金(2014Z062) 昆明醫(yī)科大學研究生創(chuàng)新基金(2016S26)
【分類號】：R741

【參考文獻】

相關期刊論文 前3條

1 高藝;朱曉波;羅燕;謝素貞;馬紅婕;郭夢翔;唐仕波;;米諾環(huán)素抑制谷氨酸誘導的大鼠視網(wǎng)膜神經(jīng)細胞凋亡[J];中國病理生理雜志;2008年10期

2 蘇新輝;豆曉鋒;張亞飛;王瑋;;小膠質細胞在神經(jīng)退行性疾病發(fā)生發(fā)展中的雙重作用[J];解剖學研究;2013年03期

3 賈s，

本文編號：1633934