本文選題：依達拉奉　切入點：腦梗死　出處：《中華醫(yī)院感染學(xué)雜志》2017年12期 　論文類型：期刊論文

【摘要】：目的探討依達拉奉在預(yù)防和控制腦梗死患者感染發(fā)生及免疫調(diào)節(jié)中的作用效果,為臨床用藥提供依據(jù)。方法選取2014年12月-2015年12月醫(yī)院收治的腦梗死患者130例,根據(jù)患者臨床治療方法的不同分為研究組和對照組,每組65例;對照組患者給予常規(guī)治療,研究組在對照組的基礎(chǔ)上加用依達拉奉進行治療;對患者的感染發(fā)生情況、紅細胞C3b受體花環(huán)率、紅細胞免疫復(fù)合物花環(huán)率和紅細胞免疫黏附促進因子等紅細胞免疫功能指標(biāo)和全血粘度、血漿粘度、血細胞比容、紅細胞聚集指數(shù)等血液流變學(xué)指標(biāo)進行觀察和比較,同時對導(dǎo)致感染發(fā)生的危險因素進行分析。結(jié)果治療1周和2周后,研究組患者的各項紅細胞免疫功能指標(biāo)和血液流變學(xué)指標(biāo)均明顯優(yōu)于對照組,且差異有統(tǒng)計學(xué)意義(P0.05);研究組感染率為10.77%,低于對照組的41.54%,且差異有統(tǒng)計學(xué)意義(P0.05);年齡、NIHHS評分、意識障礙和住院時間是腦梗死患者感染的獨立危險因素。結(jié)論腦梗死患者的感染情況嚴(yán)重,年齡、NIHHS評分、意識障礙和住院時間是腦梗死患者感染的獨立危險因素,依達拉奉在預(yù)防腦梗死患者感染以及調(diào)節(jié)患者免疫機制的過程中效果明顯。
[Abstract]:Objective to investigate the effect of edaravone on the prevention and control of infection occurrence and immune regulation in patients with cerebral infarction, and provide the basis for clinical treatment. Methods 130 patients with cerebral infarction in December 2014 -2015 year in December admitted to the hospital, according to different clinical treatment methods into study group and control group, 65 cases in each group; the control group were given routine treatment the research group, on the basis of the control group was treated with edaravone; the occurrence of infection, erythrocyte C3b receptor rosette rate of red cell immune complex rosette rate and RBC immune adherence promoting red blood cell immune factor function and blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index hemorheological indexes were observed and compared, and the risk factors for infection were analyzed. Results after 1 weeks and 2 weeks, the study group patients The red blood cell immune function index and hemorheology index were significantly better than the control group, and the difference was statistically significant (P0.05); the study group infection rate was 10.77%, lower than 41.54% in the control group, and the difference was statistically significant (P0.05); age, NIHHS score, disturbance of consciousness and hospitalization time were independent risk factors of cerebral infarction infection of patients with infection. Conclusion patients with cerebral infarction severity, age, NIHHS score, disturbance of consciousness and hospitalization time were independent risk factors of infection in patients with cerebral infarction, edaravone in the prevention of infection in patients with cerebral infarction and the effect process of regulating immune system in patients with obvious.

【作者單位】： 紹興第二醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.33

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