發(fā)布時間：2018-03-06 01:25

  本文選題：視神經(jīng)脊髓炎　切入點：磁共振成像　出處：《吉林大學》2014年碩士論文　論文類型：學位論文

【摘要】：研究目的： （1）以視神經(jīng)脊髓炎（Neuromyelitis optica,NMO）患者為研究對象，分析NMO患者頭部MRI異常率,探討NMO患者頭部MRI病灶分布特點； （2）對比分析NMO患者頭部MRI正常與頭部MRI異常組的臨床特點（性別、發(fā)病年齡、首發(fā)癥狀、復發(fā)情況、發(fā)作期EDSS評分、免疫異常情況、腦脊液特點、NMO-IgG陽性率、脊髓MRI特點）。 資料與方法； （1）本研究為回顧性研究，病例來源于2006年11月—2014年1月期間入住吉林大學附屬第一醫(yī)院神經(jīng)內(nèi)科的視神經(jīng)脊髓炎患者。記錄患者的性別、發(fā)病年齡、首發(fā)癥狀、發(fā)作期情況、相關(guān)實驗室檢查、影像學資料。 （2）對納入研究的NMO病例所有臨床的資料收集并進行分析，依據(jù)NMO患者的頭部核磁共振改變，將所有納入研究病例進行分組，即頭部MRI正常組和頭部MRI異常組，對兩組NMO患者的性別、發(fā)病年齡、首發(fā)癥狀、復發(fā)情況、發(fā)作期EDSS評分、免疫異常情況、腦脊液特點、NMO-IgG陽性率、脊髓MRI特點進行對比分析。 （3）采用SPSS17.0軟件進行統(tǒng)計分析：服從正態(tài)分布的計量資料采用均數(shù)標準差描述。非正態(tài)分布的計量資料采用中位數(shù)(median,M)及區(qū)間(range,R)描述。符合正態(tài)分布的計量資料采用t檢驗，非正態(tài)分布的計量資料描采用Mann-Whitney U檢驗，計數(shù)資料采用2檢驗。假設檢驗均以a=0．05為檢驗水準。 研究結(jié)果： （1）40例NMO患者中頭部MRI表現(xiàn)異常者21例（52．50％），皮層下、皮髓交界區(qū)7（33.33%），位于腦室附近的10例(47.62％)；發(fā)生于基底節(jié)區(qū)6例(28.57％)；發(fā)生于腦干9例(42.86％)。 （2）頭部MRI異常組和頭部MRI正常組相比發(fā)作期嚴重程度，合并自身免疫性疾病存在顯著性差異（P005）,而在性別、發(fā)病年齡、首發(fā)癥狀、復發(fā)情況、發(fā)作期EDSS評分、腦脊液特點、NMO-IgG陽性率、脊髓MRI病灶分布均無統(tǒng)計學意義（P0.05）。 結(jié)論： （1）NMO患者頭部MRI異常有較高的發(fā)生率。 （2）頭部MRI異常的NMO患者發(fā)作期病情較重，，合并自身免疫性疾病多見。
[Abstract]:Objectives of the study:. 1) to analyze the abnormal rate of head MRI in patients with NMO and to investigate the distribution of MRI lesions in the head of patients with NMO. (2) the clinical features (sex, age of onset, initial symptom, recurrence, EDSS score, immune abnormality, cerebrospinal fluid (CSF) positive rate of NMO-IgG and spinal cord MRI were compared and analyzed in NMO patients with normal head MRI and abnormal head MRI. Data and methods; This study is a retrospective study. The patients were admitted to the Department of Neurology of the first affiliated Hospital of Jilin University from November 2006 to January 2014. Related laboratory examination, imaging data. (2) collecting and analyzing all clinical data of NMO patients who were included in the study. According to the changes of head MRI in NMO patients, all cases were grouped into groups, that is, head MRI normal group and head MRI abnormal group. Sex, onset age, initial symptom, recurrence, EDSS score, immune abnormality, cerebrospinal fluid (CSF) positive rate of NMO-IgG and spinal cord MRI were compared between the two groups. (3) using SPSS17.0 software for statistical analysis: the measurement data of normal distribution are described by standard deviation of mean number, those of non-normal distribution are described by median medianum M) and interval range R.The measurement data according to normal distribution are described by t test. The measurement data of non-normal distribution were described by Mann-Whitney U test, and the counting data by 2 tests. Results of the study:. Among the 40 cases of NMO, 21 cases had abnormal MRI manifestations of head (52.50%), 733.33 (subcortical) and 733.33 (5 / 40) were located near the ventricle, 6 cases (6 cases) in basal ganglia and 42.86 (9 cases) in brainstem were located near the ventricle, 10 cases (47.62) were located in the basal ganglia, and 9 cases (42.86) were located in the brain stem in the basal ganglia area (n = 6) and in the brainstem (n = 9). (2) there was a significant difference in severity between head MRI abnormal group and head MRI normal group. There was significant difference in the severity of autoimmune diseases (P005). However, in sex, age of onset, initial symptom, recurrence, EDSS score during attack, there was a significant difference between head MRI abnormal group and head MRI normal group. The positive rate of NMO-IgG in cerebrospinal fluid (CSF) and the distribution of spinal MRI lesions were not statistically significant (P 0.05). Conclusion:. There was a high incidence of head MRI abnormality in patients with NMO. (2) NMO patients with abnormal head MRI were more serious in paroxysm and more complicated with autoimmune diseases.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R744.52

【參考文獻】

相關(guān)博士學位論文 前2條

1 武雷;視神經(jīng)脊髓炎譜系疾病的臨床研究[D];中國人民解放軍軍醫(yī)進修學院;2011年

2 姜壽峰;蛋白質(zhì)組學在多發(fā)性硬化與視神經(jīng)脊髓炎血清和腦脊液中的研究[D];浙江大學;2011年

本文編號：1572752