本文關(guān)鍵詞： 慢性特發(fā)性軸索性多神經(jīng)病 腓腸神經(jīng) 血栓調(diào)節(jié)蛋白 內(nèi)皮源性一氧化氮合酶　出處：《中風(fēng)與神經(jīng)疾病雜志》2017年01期 　論文類型：期刊論文

【摘要】：目的 研究慢性特發(fā)性軸索性多神經(jīng)病(chronic idiopathic axonal polyneuropathy,CIAP)病理改變特點(diǎn),并探索腓腸神經(jīng)炎細(xì)胞CD3、CD20、CD68抗體及其微小血管內(nèi)皮細(xì)胞膜結(jié)合性血栓調(diào)節(jié)蛋白(thrombomodulin,TM)、內(nèi)皮源性一氧化氮合酶(endothelial-nitricoxide synthase,e NOS)的表達(dá)規(guī)律。方法 10例經(jīng)過臨床、電生理、腓腸神經(jīng)活檢病理檢查證實(shí)的CIAP患者,均進(jìn)行腓腸神經(jīng)活檢標(biāo)本的常規(guī)病理組織學(xué)染色以及以抗CD3、CD20、CD68、TM、e NOS、v WF(von Willebrand factor,v WF)抗體作為第一抗體的免疫組織化學(xué)染色。結(jié)果 10例患者腓腸神經(jīng)病理檢查顯示有髓神經(jīng)纖維輕-中度減少,伴隨軸索變性和再生,部分可見輕微脫髓鞘改變,4例患者出現(xiàn)毛細(xì)血管基底膜肥厚。4例患者腓腸神經(jīng)神經(jīng)束衣間小血管周圍有散在分布的CD68陽性單核細(xì)胞浸潤。所有患者血管內(nèi)皮細(xì)胞v WF、e NOS、TM均正常表達(dá)。結(jié)論 CIAP病理特點(diǎn)為軸索損害為主,發(fā)病可能和體液免疫異常有關(guān),部分患者毛細(xì)血管基底膜肥厚提示血管內(nèi)皮細(xì)胞可能受損,但內(nèi)皮細(xì)胞功能相關(guān)蛋白表達(dá)初步提示正常。
[Abstract]:Objective to study the pathological changes of chronic idiopathic axonal polyneuropathy in chronic idiopathic axonal polyneuropathy (CIP). To investigate the expression of CD3 + CD20 + CD68 antibody and thrombomodular thrombomodulin (TMN) and endothelial-derived nitric oxide synthase (NOS) in sural neuritis cells, 10 patients with sural neuritis were enrolled in this study. Sural nerve biopsy confirmed by pathological examination in patients with CIAP, All the specimens of sural nerve biopsy were stained by routine histopathology and immunohistochemical staining of anti CD3 + CD20 WF(von Willebrand factor v WF.Results the pathological examination of sural nerve showed myelinated nerve in 10 patients. Mild to moderate fiber reduction, With axonal degeneration and regeneration, Some slight demyelinating changes were observed in 4 patients with capillary basement membrane hypertrophy. 4 patients had scattered CD68 positive monocyte infiltration around the small vessels between the sural nerve bundles. Vascular endothelial cells were found in all patients. Conclusion the pathological features of CIAP are axonal damage. The pathogenesis may be related to the abnormal humoral immunity. The hypertrophy of capillary basement membrane suggests that vascular endothelial cells may be damaged, but the expression of function-related proteins of endothelial cells may be normal.
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本文編號(hào)：1549525