本文關鍵詞： 腦梗死 C反應蛋白質 脂蛋白類 LDL　出處：《河北醫(yī)科大學學報》2017年05期 　論文類型：期刊論文

【摘要】：目的檢測不同TOAST分型急性腦梗死患者血清高敏C反應蛋白(high sensitive-C reactive protein,hs-CRP)和低密度脂蛋白(low density lipoprotein,LDL)水平,探討hs-CRP和LDL在不同類型腦梗死急性期的作用及臨床意義。方法選取腦梗死患者374例為病例組,健康志愿者60例為正常對照組。病例組患者按照TOAST分型分為大動脈粥樣硬化組(large-artery atherosclerosis,LAA)158例、小動脈閉塞組(small-artery occlusion,SAO)171例和心源性栓塞組(cardioembolism,CE)45例。所有受試者于次日清晨空腹抽取肘靜脈血3mL,測定血清hs-CRP和LDL水平。結果 LAA、SAO、CE組美國國立衛(wèi)生研究院卒中量表(National Institute of Health stroke scale,NIHSS)評分、收縮壓、舒張壓明顯高于對照組,LAA組和CE組NIHSS評分高于SAO組,LAA、SAO組收縮壓高于CE組。LAA、SAO組吸煙、糖尿病發(fā)生率高于對照組和CE組,SAO組飲酒發(fā)生率高于對照組,LAA、SAO、CE組高血壓、高脂血癥、心臟病發(fā)生率高于對照組,CE組心臟病發(fā)生率高于LAA組和SAO組。LAA、SAO、CE組血清hs-CRP水平高于對照組,CE組血清hs-CRP水平高于LAA、SAO組,LAA組血清hsCRP水平高于SAO組。LAA、SAO組血清LDL水平高于對照組(P0.05)。急性腦梗死患者血清hs-CRP水平與LDL、NIHSS評分呈正相關(rs=0.164、0.183,P0.05)。二分類Logistic回歸分析結果顯示,收縮壓、hs-CRP是心源性腦栓死的危險因素。結論在TOAST亞型中,血清hs-CRP可作為CE的危險因素,成為腦梗死發(fā)病早期判定病因學分類的指標。LDL有望成為LAA的特異性生化指標,對早期預測LAA有重要臨床價值。
[Abstract]:Objective to detect the serum Gao Min C-reactive protein high sensitive-C reactive protein in patients with acute cerebral infarction according to different TOAST classification. Hs-CRP) and low density lipoprotein (LDL). To explore the role and clinical significance of hs-CRP and LDL in acute phase of different types of cerebral infarction methods 374 patients with cerebral infarction were selected as the case group. According to TOAST classification, 60 healthy volunteers were divided into large artery atherosclerosis group and large artery atherosclerosis group. LAA)158, small artery occlusion and cardioembolism were observed in 171patients with small artery occlusion and cardioembolism. Cases of CE)45. All subjects took 3mL of blood from cubital vein on an empty stomach the next morning to determine the levels of serum hs-CRP and LDL. In CE group, the National Institute of Health stroke scale (NIHSS) was used. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly higher than those in control group (LAA group) and CE group (P < 0.05). The incidence of diabetes mellitus was higher than that of control group and CE group. The incidence of alcohol consumption in SAO group was higher than that in control group. The incidence of hypertension, hyperlipidemia and heart disease in SAO group was higher than that in control group. The incidence of heart disease in CE group was higher than that in LAA group and SAO group. The serum hs-CRP level in CE group was higher than that in control group. The hs-CRP level in CE group was higher than that in LAA group. The level of serum hsCRP in SAO group was higher than that in SAO group. The serum LDL level in SAO group was higher than that in control group (P 0.05). There was a positive correlation between serum hs-CRP level and NIHSS score in patients with acute cerebral infarction (ACI). The results of two classification Logistic regression analysis showed that systolic blood pressure (SBP) hs-CRP was the risk factor of cardiogenic brain thrombus death. Conclusion it is in TOAST subtype. Serum hs-CRP can be used as a risk factor of CE, and it is expected to be a specific biochemical index of LAA in the early stage of cerebral infarction. It has important clinical value for early prediction of LAA.
【作者單位】： 河北醫(yī)科大學第二醫(yī)院神經內科;河北省定州市第二醫(yī)院神經內科;
【分類號】：R743.33
【正文快照】： 腦梗死通常是指腦部的血液供應障礙或腦組織局部缺血缺氧而造成的局部腦組織壞死,又稱缺血性腦卒中,其主要原因是腦血管出現(xiàn)了動脈粥樣硬化和血栓形成,使腦部血管逐漸狹窄或者完全閉塞,最終導致血液供應障礙。對于缺血性卒中不同病因分型要采取針對性的治療方法�，F(xiàn)已證實急性

【相似文獻】

相關期刊論文 前10條

1 李桂英,孟秋云;欣坦治療急性腦梗死42例療效觀察[J];現(xiàn)代中西醫(yī)結合雜志;2002年07期

2 馬可夫,楮曉凡;急性腦梗死患者血清血管內皮生長因子的測定[J];中風與神經疾病雜志;2003年01期

3 鄭曉紅;硫酸鎂佐治急性腦梗死40例療效觀察[J];臨床醫(yī)藥實踐;2003年09期

4 郭百海;周麗;;經顱超聲多普勒診斷急性腦梗死的價值[J];中國實用內科雜志;2006年S2期

5 翁�；�;;超敏C-反應蛋白與急性腦梗死的相關性分析[J];廣西醫(yī)科大學學報;2007年01期

6 薛新宏;王大力;彭延波;張江;高素玲;常莉莎;張麗;趙曉晶;;急性腦梗死患者血清神經元特異性烯醇化酶的變化[J];華北煤炭醫(yī)學院學報;2007年06期

7 郭秀鳳;李運剛;李化勇;夏英凱;;急性腦梗死患者血漿單核細胞趨化蛋白-1和組織因子的變化[J];中華老年心腦血管病雜志;2008年10期

8 馬莉莎;劉仲華;隋彩珍;;單唾液酸四己糖神經節(jié)苷脂治療急性腦梗死64例療效觀察[J];山東醫(yī)藥;2009年05期

9 王永萍;;高同型半胱氨酸血癥與急性腦梗死關系探討[J];社區(qū)醫(yī)學雜志;2009年17期

10 趙學社;;68例急性腦梗死患者臨床檢測分析[J];中國現(xiàn)代藥物應用;2010年09期

相關會議論文 前10條

1 黃菊明;;探討神經元特異性烯醇化酶在急性腦梗死患者中的臨床價值[A];2007年浙江省神經病學學術年會論文匯編[C];2007年

2 張允嶺;;急性腦梗死毒損腦絡學說基礎與臨床研究進展[A];第二屆中西醫(yī)結合腦病診治新進展高級研討班專家講義及論文匯編[C];2010年

3 毛銳;聶志余;靳令經;封亮;陳玉輝;李云霞;;頸動脈粥樣硬化性狹窄或閉塞所致急性腦梗死類型研究[A];中華醫(yī)學會第十三次全國神經病學學術會議論文匯編[C];2010年

4 張小雨;張鳳;王棟;張媛媛;李曉紅;;急性腦梗死后血糖水平與輕度認知功能損害關系研究[A];2011全國老年癡呆與衰老相關疾病學術會議第三屆山東省神經內科醫(yī)師（學術）論壇論文匯編[C];2011年

5 耿亞蘭;鐘傳林;楊清樺;;急性腦梗死患者超敏C-反應蛋白監(jiān)測的臨床意義[A];貴州省醫(yī)學會第八屆神經病學年會論文集[C];2010年

6 趙路清;崔愛勤;劉錦峰;張運生;王惠聰;郭學英;劉改生;郭志昌;;不同劑量金爾倫治療急性腦梗死的臨床研究[A];中華醫(yī)學會第七次全國神經病學學術會議論文匯編[C];2004年

7 吳云成;趙永波;談永基;喬健;呂傳真;;血清神經元特異性烯醇化酶與急性腦梗死患者遠期預后的相關性研究[A];中華醫(yī)學會第七次全國神經病學學術會議論文匯編[C];2004年

8 劉軍;富昭;魚博浪;張明;丁暉;吳蘭琴;邵瑩;劉慶祿;;氫質子磁共振波譜在急性腦梗死診斷中的價值[A];人體斷面數(shù)據獲取與圖像處理研討會論文匯編[C];2005年

9 蘇慶杰;陳志斌;蔡美華;王W，

本文編號：1484899